{"id":513,"date":"2025-09-22T09:34:34","date_gmt":"2025-09-22T00:34:34","guid":{"rendered":"https:\/\/ito-pain.com\/blog\/?p=513"},"modified":"2025-09-22T09:39:15","modified_gmt":"2025-09-22T00:39:15","slug":"post-513","status":"publish","type":"post","link":"https:\/\/ito-pain.com\/blog\/post-513\/","title":{"rendered":"\u75db\u307f\u306e\u7d4c\u8def\u306f\u7537\u5973\u4e00\u7dd2\u3067\u306f\u306a\u3044\uff1f"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/dce9ee093813f31a1820f7d079151c9d.png\" alt=\"\" class=\"wp-image-516\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/dce9ee093813f31a1820f7d079151c9d.png 750w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/dce9ee093813f31a1820f7d079151c9d-400x267.png 400w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure>\n<\/div>\n\n\n<p>\u6700\u8fd1\u3001\u300cNature\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d\u3092\u8a3a\u7642\u5f8c\u306b\u659c\u3081\u8aad\u307f\u3057\u3066\u3044\u308b\u6642\u3001\u4ee5\u524d\u3001\u5370\u8c61\u306b\u5f37\u304f\u6b8b\u3063\u3066\u3044\u305f\u75db\u307f\u306e\u7814\u7a76\u8ad6\u6587\u306b\u3064\u3044\u3066\u306e\u5185\u5bb9\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u306e\u3067\u3001\u4eca\u56de\u306f\u3053\u308c\u306b\u3064\u3044\u3066\u306e\u8a71\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u75db\u307f\u306e\u7d4c\u8def\u306f\u7537\u5973\u4e00\u7dd2\u3067\u306f\u306a\u3044\u3089\u3057\u3044<\/strong><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/ebb9b5e9bcad182bc0b58562240825b7.png\" alt=\"\" class=\"wp-image-517\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/ebb9b5e9bcad182bc0b58562240825b7.png 750w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/ebb9b5e9bcad182bc0b58562240825b7-400x267.png 400w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure>\n<\/div>\n\n\n<p>\u6162\u6027\u75bc\u75db\u306b\u6027\u5dee\u304c\u3042\u308a\u3001\u5973\u6027\u306e\u65b9\u304c\u591a\u3044\u3053\u3068\u306f\u4ee5\u524d\u3088\u308a\u8a00\u308f\u308c\u3066\u3044\u305f\u3053\u3068\u3067\u3059\u3002\u4f8b\u3068\u3057\u3066\u3001\u7dda\u7dad\u7b4b\u75db\u75c7\u306f\u5973\u6027\u304c7\u500d\u591a\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u4ee5\u5916\u306b\u3082\u3001\u6027\u5dee\u306e\u3042\u308b\u75be\u60a3\u306f\u591a\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u75db\u307f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u7537\u5973\u3067\u9055\u3046\u3089\u3057\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u306f\u3064\u3044\u6700\u8fd1\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>2009\u5e74\u306b\u30ab\u30ca\u30c0\u306e\u30de\u30ae\u30eb\u5927\u5b66\u3067\u3001\u3054\u304f\u8efd\u3044\u89e6\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u5f37\u3044\u75db\u307f\u3092\u611f\u3058\u308b\u75db\u899a\u904e\u654f\u306e\u4ed5\u7d44\u307f\u3092\u30de\u30a6\u30b9\u3067\u8abf\u3079\u3066\u3044\u305f\u3068\u3053\u308d\u3001\u3053\u306e\u30bf\u30a4\u30d7\u306e\u75db\u899a\u904e\u654f\u53cd\u5fdc\u304c\u96c4\u96cc\u3067\u5927\u304d\u304f\u7570\u306a\u3063\u3066\u3044\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u6700\u521d\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u767a\u898b\u4ee5\u524d\u306f\u3001\u96cc\u306e\u30db\u30eb\u30e2\u30f3\u5468\u671f\uff08\u751f\u7406\uff09\u306b\u3088\u3063\u3066\u7d50\u679c\u304c\u8907\u96d1\u306b\u306a\u308b\u3053\u3068\u3092\u61f8\u5ff5\u3057\u3066\u3001\u6163\u4f8b\u3068\u3057\u3066\u9577\u5e74\u3001\u75bc\u75db\u7814\u7a76\u306b\u96c4\u3060\u3051\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3001\u3053\u306e\u7814\u7a76\u3092\u304d\u3063\u304b\u3051\u306b\u3001\u4e00\u9023\u306e\u75bc\u75db\u53cd\u5fdc\u306e\u6027\u5dee\u306b\u76ee\u304c\u5411\u3051\u3089\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u6210\u679c\u3082\u51fa\u59cb\u3081\u3001\u3042\u308b\u7a2e\u306e\u75bc\u75db\u7d4c\u8def\u306b\u306f\u6027\u5dee\u304c\u304b\u306a\u308a\u3042\u308a\u3001\u514d\u75ab\u7d30\u80de\u3084\u30db\u30eb\u30e2\u30f3\u304c\u3001\u3055\u307e\u3056\u307e\u306a\u53cd\u5fdc\u306b\u91cd\u5927\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6162\u6027\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u5834\u5408\u306e\u30de\u30a6\u30b9\u306e\u6027\u5dee\u306b\u3088\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u9055\u3044\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/8f16b251d9a3c3b9d826c7d577e1128d.jpg\" alt=\"\" class=\"wp-image-514\" style=\"width:840px;height:auto\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/8f16b251d9a3c3b9d826c7d577e1128d.jpg 750w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/8f16b251d9a3c3b9d826c7d577e1128d-400x267.jpg 400w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><figcaption class=\"wp-element-caption\"><strong>\u300cNature\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d Vol. 16 No. 6 DOI: 10.1038\/ndigest.2019.190622\u3088\u308a\u629c\u7c8b<\/strong><\/figcaption><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><\/blockquote>\n\n\n\n<p>\u8133\u3084\u810a\u9ac4\u3092\u4f53\u306e\u4ed6\u306e\u90e8\u4f4d\u3068\u7d50\u3076\u672b\u68a2\u795e\u7d4c\u304c\u50b7\u3064\u304f\u3068\u3001\u75db\u307f\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u96c4\u306e\u30de\u30a6\u30b9\u3067\u306f\u3001\u3053\u306e\u53cd\u5fdc\u306f\u810a\u9ac4\u306b\u3042\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u3044\u3046\u514d\u75ab\u7d30\u80de\u306e\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff14(TLR\uff14)\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u3001\u96cc\u3067\u306fT\u7d30\u80de\u304c\u75bc\u75db\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3068\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7d4c\u8def\u306e\u9055\u3044\u306b\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3089\u3057\u304f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u6709\u7121\u3067\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5165\u308c\u66ff\u308f\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u203b\u4e16\u754c\u3067\u521d\u3081\u30662003 \u5e74\u306b\u810a\u9ac4\u306e\u4e2d\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff08\u514d\u75ab\u7d30\u80de\u306e\uff11\u3064\uff09\u306e\u6d3b\u6027\u5316\u304c\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u82f1\u56fd\u79d1\u5b66\u8a8cNature\u3067\u767a\u8868\u3057\u305f\u306e\u306f\u3001\u65e5\u672c\u306e\u4e5d\u5927\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u75db\u307f\u306b\u5bfe\u3057\u3066\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u307e\u3060\u307e\u3060\u591a\u3059\u304e\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6027\u5dee\u306b\u3088\u308b\u75db\u307f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u9055\u3044\u306f\u3001\u5916\u304b\u3089\u306f\u540c\u3058\u306b\u898b\u3048\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u75db\u307f\u304c\u3001\u4f53\u5185\u3067\u540c\u3058\u3053\u3068\u304c\u8d77\u304d\u3066\u3044\u308b\u3068\u4eee\u5b9a\u3059\u308b\u8a33\u306b\u306f\u3044\u304b\u306a\u3044\u3053\u3068\u3092\u3053\u306e\u8ad6\u6587\u7d50\u679c\u306f\u793a\u3057\u305f\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/image-9-800x534.png\" alt=\"\" class=\"wp-image-515\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/image-9-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/image-9-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/09\/image-9.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p>\u75db\u307f\u306f\u81ea\u899a\u75c7\u72b6\u3067\u3042\u308a\u3001\u306a\u304b\u306a\u304b\u5916\u90e8\u304b\u3089\u305d\u306e\u7a0b\u5ea6\u3092\u985e\u63a8\u3059\u308b\u306e\u306f\u81f3\u96e3\u306e\u696d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u306b\u6765\u9662\u3055\u308c\u305f\u60a3\u8005\u3055\u3093\u5168\u54e1\u75db\u307f\u304c\u7de9\u548c\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u30011\u4eba1\u4eba\u75db\u307f\u306e\u6027\u72b6\u306f\u7570\u306a\u308b\u3082\u306e\u3068\u3057\u3066\u771f\u646f\u306b\u5411\u304d\u5408\u3046\u59ff\u52e2\u306f\u3001\u81e8\u5e8a\u5bb6\u3068\u3057\u3066\u5927\u4e8b\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n\n\n\n<p>\u203b\uff11\uff09\uff12\uff09\u306f\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u5831\u544a<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\uff11\uff09 Nat Neurosci. 2015 Aug;18(8):1081-3. doi: 10.1038\/nn.4053. Epub 2015 Jun 29. Different immune cells mediate mechanical pain hypersensitivity in male and female mice<\/p>\n\n\n\n<p>\uff12\uff09 J Neurosci. 2011 Oct 26;31(43):15450-4. doi: 10.1523\/JNEUROSCI.3859-11.2011. Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice<\/p>\n<\/blockquote>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\u3001\u300cNature\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d\u3092\u8a3a\u7642\u5f8c\u306b\u659c\u3081\u8aad\u307f\u3057\u3066\u3044\u308b\u6642\u3001\u4ee5\u524d\u3001\u5370\u8c61\u306b\u5f37\u304f\u6b8b\u3063\u3066\u3044\u305f\u75db\u307f\u306e\u7814\u7a76\u8ad6\u6587\u306b\u3064\u3044\u3066\u306e\u5185\u5bb9\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u306e\u3067\u3001\u4eca\u56de\u306f\u3053\u308c\u306b\u3064\u3044\u3066&#8230;<\/p>\n","protected":false},"author":3,"featured_media":516,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"class_list":["post-513","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-4"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/posts\/513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/comments?post=513"}],"version-history":[{"count":3,"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/posts\/513\/revisions"}],"predecessor-version":[{"id":520,"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/posts\/513\/revisions\/520"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/media\/516"}],"wp:attachment":[{"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/media?parent=513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ito-pain.com\/blog\/wp-json\/wp\/v2\/categories?post=513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}