{"id":472,"date":"2025-08-28T08:22:36","date_gmt":"2025-08-27T23:22:36","guid":{"rendered":"https:\/\/ito-pain.com\/blog\/?p=472"},"modified":"2025-08-28T09:41:16","modified_gmt":"2025-08-28T00:41:16","slug":"post-472","status":"publish","type":"post","link":"https:\/\/ito-pain.com\/blog\/post-472\/","title":{"rendered":"\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306b\u5bfe\u3057\u3066\u6700\u3082\u52b9\u679c\u306e\u3042\u308b\u85ac\u306f\uff1f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u4e16\u754c\u7684\u306b\u6709\u52b9\u3068\u3055\u308c\u308b\u85ac\u306f\u4f55\uff1f<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/236953569ce63603a106270aebe990fd.png\" alt=\"\" class=\"wp-image-482\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/236953569ce63603a106270aebe990fd.png 750w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/236953569ce63603a106270aebe990fd-400x267.png 400w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure>\n<\/div>\n\n\n<p>\u3053\u3093\u306b\u3061\u306f\u3001\u3044\u3068\u3046\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u306e\u9662\u9577\u306e\u4f0a\u85e4\u3067\u3059\u3002\u4eca\u56de\u306f\u3001\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u85ac\u306e\u9078\u629e\u3067\u3088\u304f\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3092\u3082\u3068\u306b\u3001\u4e16\u754c\u7684\u306b\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306b\u6709\u52b9\u3068\u63a8\u5968\u3055\u308c\u308b\u85ac\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>2016\u5e74\u306b\u30e9\u30f3\u30bb\u30c3\u30c8\u30cb\u30e5\u30fc\u30ed\u30fc\u30eb\u3088\u308a\u5831\u544a\u3055\u308c\u305f\u30e1\u30bf\u89e3\u6790\u306e\u7d50\u679c\u304c\u3001\u8a55\u4fa1\u57fa\u6e96\u3068\u3057\u3066\u3088\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u3053\u306e\u6587\u732e\u306e\u5185\u5bb9\u306b\u6cbf\u3063\u3066\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u85ac\u306e\u52b9\u679c\u3068\u526f\u4f5c\u7528\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u307f\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u52b9\u679c\u3092\u307f\u308b\u306b\u3042\u305f\u3063\u3066\u3001NNT\uff08Number Needed to Treat\uff09\u3068NNH\uff08Number Needed to Harm\uff09\u3068\u3044\u3046\u5024\u306b\u3064\u3044\u3066\u306e\u7406\u89e3\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>NNT\u3068\u306f\u3001\u4f55\u4eba\u6cbb\u7642\u3057\u30661\u4eba\u306b\u6709\u52b9\u3067\u3042\u3063\u305f\u306e\u304b\u3092\u793a\u3059\u5024\u3067\u5c0f\u3055\u3044\u5024\u307b\u3069\u3001\u6cbb\u7642\u52b9\u679c\u304c\u9ad8\u3044\u3053\u3068\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002 \u4e00\u65b9NNH\u306f\u3001\u4f55\u4eba\u6cbb\u7642\u3057\u305f\u30891\u4eba\u306b\u526f\u4f5c\u7528\u304c\u767a\u751f\u3059\u308b\u304b\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u5024\u304c\u4f4e\u3044\u307b\u3069\u3001\u526f\u4f5c\u7528\u306e\u767a\u751f\u304c\u5927\u304d\u304f\u306a\u308b\u3053\u3068\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\uff09<br>NNT2\uff1a\u85ac\u3092\u6295\u85ac\u3057\u30662\u4eba\u306b1\u4eba\u306f\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 NNT10\u306a\u3089\u3070\u300110\u4eba\u6cbb\u7642\u3057\u30661\u4eba\u3060\u3051\u52b9\u679c\u304c\u3042\u3063\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002 \u3053\u306e\u5834\u5408NNT2\u306e\u85ac\u304c\u6cbb\u7642\u52b9\u679c\u304c\u9ad8\u3044\u3053\u3068\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\uff09<br>NNH2\uff1a\u85ac\u3092\u6295\u85ac\u3057\u30662\u4eba\u306b1\u4eba\u306b\u526f\u4f5c\u7528\u304c\u767a\u751f\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u305d\u308c\u3067\u306f\u3001\u4e0b\u306e\u8868\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"340\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/image-17-800x340.png\" alt=\"\" class=\"wp-image-480\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/image-17-800x340.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/image-17-400x170.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2025\/08\/image-17.png 942w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p>\u4e0a\u306e\u8868\u306f\u3001\u53c2\u8003\u6587\u732eLancet Neurol.&nbsp;2015 Feb;14(2):162-73.&nbsp;doi: 10.1016\/S1474-4422(14)70251-0.\u3088\u308a\u5024\u3092\u629c\u7c8b\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u8a66\u9a13\u306e55%\u306f\u3001\u7cd6\u5c3f\u75c5\u6027\u75bc\u75db\u6027\u591a\u767a\u795e\u7d4c\u969c\u5bb3\u307e\u305f\u306f\u5e2f\u72b6\u75b1\u75b9\u5f8c\u795e\u7d4c\u75db\u3067\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7565\u8a9e\uff1a<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TCA\u30fb\u30fb\u30fb\u4e09\u74b0\u7cfb\u6297\u3046\u3064\u85ac\uff1a\u4e3b\u306b\u30c8\u30ea\u30d7\u30bf\u30ce\u30fc\u30eb\ud83c\udd2c25\uff5e150\u338e\u4f7f\u7528\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li>SNRI\u30fb\u30fb\u30fb\u30bb\u30ed\u30c8\u30cb\u30f3-\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u30a4\u30f3\u31f6\u30d3\u30bf\u30fc\uff1a\u6297\u3046\u3064\u85ac \u30c7\u30e5\u30ed\u30ad\u30bb\u30c1\u30f3\uff08\u30b5\u30a4\u30f3\u30d0\u30eb\u30bf\ud83c\udd2c20\uff5e120\u338e\uff09\u3068\u30d9\u30f3\u30e9\u30d5\u30a1\u30ad\u30b7\u30f3\uff08\u30a4\u30d5\u30a7\u30af\u30b5\u30fc\ud83c\udd2c150\uff5e225\u338e\u6295\u4e0e\uff09<\/li>\n\n\n\n<li>Pregabalin\u30fb\u30fb\u30fb\u30d7\u30ec\u30ac\u30d0\u30ea\u30f3\uff1a\u30ea\u30ea\u30ab\ud83c\udd2c150 \uff5e600\u338e<\/li>\n\n\n\n<li>Gabapentin\u30fb\u30fb\u30fb\u30ac\u30d0\u30da\u30f3\u30c1\u30f3\uff1a\u6297\u3066\u3093\u304b\u3093\u85ac \u30ac\u30d0\u30da\u30f3\ud83c\udd2c900\uff5e3600\u338e\/\u30ac\u30d0\u30da\u30f3\u30c1\u30f3\u30a8\u30ca\u30ab\u30d3\u30eb<\/li>\n\n\n\n<li>Tramadol\u30fb\u30fb\u30fb\u30c8\u30e9\u30de\u30c9\u30fc\u30eb\uff1a\u5f31\u3044\u30aa\u30d4\u30aa\u30a4\u30c9 \u30c8\u30e9\u30de\u30c9\u30fc\u30eb\ud83c\udd2c\uff5e400\u338e<\/li>\n\n\n\n<li>Strong opioids\u30fb\u30fb\u30fb\u5f37\u3044\u30aa\u30d4\u30aa\u30a4\u30c9\uff1a\u30aa\u30ad\u30b7\u30b3\u30c9\u30f310\uff5e120\u338e \u30e2\u30eb\u30d2\u30cd90\uff5e240\u338e<\/li>\n\n\n\n<li>Capsaicin8\uff05\u30fb\u30fb\u30fb\u30ab\u30d7\u30b5\u30a4\u30b7\u30f38\uff05\uff1a\u30c8\u30a6\u30ac\u30e9\u30b7\u306e\u6210\u5206\uff18\uff05\uff08\u75db\u307f\u53d7\u5bb9\u4f53\u306eTRPV1\u306b\u4f5c\u7528\u3057\u672b\u68a2\u795e\u7d4c\u306e\u75db\u307f\u3092\u7de9\u548c\u3057\u307e\u3059\u3002\uff09<\/li>\n\n\n\n<li>BTX-A\u30fb\u30fb\u30fb\u30dc\u30c8\u30c3\u30af\u30b9A:\u5358\u56de50\uff5e200\u5358\u4f4d\u6295\u4e0e\uff1a\u672b\u68a2\u795e\u7d4c\u5f1b\u7de9\u85ac\uff08\u4e00\u822c\u7684\u306b\u306f\u3001\u7f8e\u5bb9\u76ee\u7684\u3084\u773c\u77bc\u75d9\u6523\u3084\u659c\u9838\u306a\u3069\u7b4b\u8089\u3092\u5f1b\u7de9\u3055\u305b\u308b\u306e\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u30e1\u30bf\u89e3\u6790\u306b\u4f7f\u7528\u3055\u308c\u305f\u6587\u732e\u306f\u5c40\u6240\u306e\u75bc\u75db\u767a\u751f\u90e8\u4f4d\u306a\u3069\u306b\u5bfe\u3057\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u304b\u306a\u308a\u5c02\u9580\u7684\u306a\u4f7f\u7528\u3067\u3059\u3002\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1aLancet Neurol. 2015 Feb;14(2):162-73. doi: 10.1016\/S1474-<code>4422(14)70251-0.<\/code><\/p>\n\n\n\n<p>\u3053\u306e\u89e3\u6790\u7d50\u679c\u306b\u3088\u308b\u3068\u3001NNT\u304c\u6700\u3082\u5c0f\u3055\u3044TCA\uff08\u4e09\u74b0\u7cfb\u6297\u3046\u3064\u85ac\uff09\u304c\u6700\u3082\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u6cbb\u7642\u306b\u6709\u52b9\u306a\u7d50\u679c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002Strong 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