{"id":1615,"date":"2026-10-19T09:19:33","date_gmt":"2026-10-19T00:19:33","guid":{"rendered":"https:\/\/ito-pain.com\/blog\/?p=1615"},"modified":"2026-10-19T09:48:57","modified_gmt":"2026-10-19T00:48:57","slug":"post-1615","status":"publish","type":"post","link":"https:\/\/ito-pain.com\/blog\/post-1615\/","title":{"rendered":"\u6307\u3092\u66f2\u3052\u308b\u3068\u75db\u3044 \u3078\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3068\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\u3068\u6bcd\u6307\u306eCM\u95a2\u7bc0\u75c7\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n<p 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class=\"wp-block-heading\">HOA\u3068\u306f\u3001<\/h2>\n\n\n\n<p 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class=\"wp-block-heading\">\u624b\u306e\u89e3\u5256<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"448\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-23-800x448.png\" alt=\"\" class=\"wp-image-1641\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-23-800x448.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-23-400x224.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-23-768x430.png 768w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-23.png 875w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">https:\/\/www.med.osaka-u.ac.jp\/pub\/imed3\/disease\/d-immu02-4.html \u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\uff5c\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 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class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306bsymptomatic\u3000HOA\u306e\u8a3a\u65ad\u57fa\u6e96\u306b\u3064\u3044\u3066\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\u306e1990\u5e74ACR\u5206\u985e\u57fa\u6e96\uff08Arthritis &amp; Rheum 1990\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u611f\u5ea692%\u3001\u7279\u7570\u5ea698%\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff11\uff1a\u624b\u306e\u75db\u307f\u3001\u3046\u305a\u304d\u3001\u3042\u308b\u3044\u306f\u3053\u308f\u3070\u308a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff12\uff1a10\u95a2\u7bc0\uff08\u5de6\u53f3\u306e\u6bcd\u6307CM\u3001\u7b2c2\uff653\u6307DIP\u3068PIP\uff09\u306e\u3046\u30612\u95a2\u7bc0\u4ee5\u4e0a\u306b\u786c\u6027\u816b<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-22-800x534.png\" alt=\"\" class=\"wp-image-1640\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-22-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-22-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-22-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-22.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">https:\/\/www.med.osaka-u.ac.jp\/pub\/imed3\/disease\/d-immu02-4.html \u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\uff5c\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 \u547c\u5438\u5668\u30fb\u514d\u75ab\u5185\u79d1\u5b66\u3088\u308a\u629c\u7c8b\u4e00\u90e8\u5909\u66f4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u3000\uff1aMP\u95a2\u7bc0\u306e\u816b\u8139\u306f2\u95a2\u7bc0\u4ee5\u4e0b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4&nbsp; a\uff1a2\u3064\u4ee5\u4e0a\u306eDIP\u95a2\u7bc0\u3067\u786c\u6027\u816b\u8139\u30fb\u30fb\u30fb\uff08\u786c\u6027\u816b\u8139\uff1a\u786c\u304f\u89e6\u308c\u308b\u816b\u308c\u306e\u3053\u3068\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4 \uff42:10\u95a2\u7bc0\u306e\u3046\u30611\u95a2\u7bc0\u4ee5\u4e0a\u306e\u5909\u5f62<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;1\uff0b2\uff0b3+ (4a or 4b)\u3067\u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\u3068\u5206\u985e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u306e\u8a3a\u65ad\u306b\u306f\u3001\u30ec\u30f3\u30c8\u30b2\u30f3\u6240\u898b\u304c\u5165\u3063\u3066\u3044\u306a\u3044\u3067\u3059\u304c\u30012009\u5e74\u3001EULAR\u304b\u3089\u8a3a\u65ad\u306e\u305f\u3081\u306e\u6839\u62e0\u306b\u57fa\u3065\u3044\u305frecommendation\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u30ec\u30f3\u30c8\u30b2\u30f3\u6240\u898b\u3082\u542b\u3081\u3088\u308a\u7dcf\u5408\u7684\u306b\u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\u306e\u8a3a\u65ad\u3092\u884c\u3046\u3088\u3046\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u65e5\u672c\u4eba\u306e\u624b\u6307\u306b\u304a\u3051\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\uff08HOA\uff09\u306e\u7f79\u60a3\u7387\u306f\u4e16\u754c\u7684\u306b\u307f\u3066\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8af8\u5916\u56fd\u8abf\u67fb\u3068\u6bd4\u8f03\u3057\u3066\u65e5\u672c\u4eba\u3067\u306fHOA\u306f\u3001\u5727\u5012\u7684\u306b\u9ad8\u3044\u7d50\u679c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eba\u7a2e\u306e\u5f71\u97ff\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001OA\u306e\u767a\u75c7\u8981\u56e0\u3068\u3057\u3066\u907a\u4f1d\u5b50\u7684\u306a\u95a2\u4e0e\u306f\u69d8\u3005\u306a\u7814\u7a76\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306b\u65e5\u672c\u3067\u8abf\u67fb\u3055\u308c\u305f\u3001HOA\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mod Rheumatol. 2016 Sep;26(5):767-73. doi: 10.3109\/14397595.2015.1130673. Epub 2016 Feb 16.\u3000Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rie Kodama, Shigeyuki Muraki, Hiroyuki Oka, Toshiko Iidaka, Masatoshi Teraguchi, Ryohei Kagotani, Yoshiki Asai, Munehito Yoshida, Yutaka Morizaki, Sakae Tanaka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Noriko Yoshimura<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ROAD\u7814\u7a76\u306e\u7b2c3\u6b21\u8abf\u67fb\u306f\u30012012\u5e74\u304b\u30892013\u5e74\u306b\u304b\u3051\u3066\u5b9f\u65bd\u3055\u308c\u3001\u7b2c3\u6b21\u8abf\u67fb\u306b\u306f2566\u540d\u304c\u53c2\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u30ea\u30a6\u30de\u30c1\u306e\u65e2\u5f80\u304c\u3042\u308b\u4eba\u3001\u307e\u305f\u306fRA\u6cbb\u7642\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b27\u540d\u3092\u9664\u5916\u3057\u305f\u4e0a\u3067\u3001\u4e21\u624b\u306eX\u7dda\u64ae\u5f71\u3092\u53d7\u3051\u305f1535\u540d\u306e\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u306b\u7528\u3044\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u306e\u5bfe\u8c61\u8005\u306f\u5168\u54e1\u3001\u65e5\u672c\u4eba\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5408\u8a08\u4eba\u6570\u306f\u30011535\u4eba\u3067\u5e73\u5747\u5e74\u9f62\u306f\u300165.6\uff08\u00b113.0\uff09\u6b73<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5185\u8a33\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7537\u6027\u3000507\u4eba\u3000 \u3000\u5e73\u5747\u5e74\u9f62\u306f66.3\uff08\u00b113.7\uff09\u6b73<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5973\u6027\u30001028\u4eba\u3000\u5e73\u5747\u5e74\u9f62\u306f\u300165.3\uff08\u00b112.6\uff09\u6b73<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\uff1a\uff08\u00b1\u306f\u3001\u6a19\u6e96\u504f\u5dee\u3067\u3059\u3002\u304a\u304a\u3088\u305d\u306e\u5e73\u5747\u5e74\u9f62\u306e\u3070\u3089\u3064\u304d\u306b\u3064\u3044\u3066\u793a\u3057\u3066\u3044\u307e\u3059\u3002\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306f\u3058\u3081\u306b<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ec\u30f3\u30c8\u30b2\u30f3\u306b\u3088\u308bHOA\u306e\u5206\u985e\u3068\u9aa8\u3073\u3089\u3093\u50cf\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\u6539\u5909KL\u5206\u985e\uff08modified KL scale\uff09<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u6539\u5909KL\u5206\u985e\u306f0\u304b\u30894\u306e\u7b49\u7d1a\u3067\u8a55\u4fa1\u3055\u308c\u30010\uff1dOA\u306a\u3057\u30011\uff1d\u9aa8\u68d8\uff08\u4ee5\u4e0bOP\uff09\u304a\u3088\u3073\/\u307e\u305f\u306f\u95a2\u7bc0\u88c2\u9699\u72ed\u5c0f\u5316\uff08\u4ee5\u4e0bJSN\uff09\u306e\u7591\u3044\u30012\uff1d\u660e\u3089\u304b\u306a\u5c0f\u3055\u306aOP\u304a\u3088\u3073\/\u307e\u305f\u306f\u8efd\u5ea6\u306eJSN\u30013\uff1d\u4e2d\u7b49\u5ea6\u306eOP\u304a\u3088\u3073\/\u307e\u305f\u306f\u4e2d\u7b49\u5ea6\u306eJSN\uff08\u786c\u5316\u3084\u3073\u3089\u3093\u3092\u4f34\u3046\u5834\u5408\u3042\u308a\uff09\u30014\uff1d\u5927\u304d\u306aOP\u304a\u3088\u3073\/\u307e\u305f\u306f\u91cd\u5ea6\u306eJSN\uff08\u786c\u5316\u3084\u3073\u3089\u3093\u3092\u4f34\u3046\u5834\u5408\u3042\u308a\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001Altman\u3089\u306e\u30a2\u30c8\u30e9\u30b9\u306b\u57fa\u3065\u304d\u3001DIP\u95a2\u7bc0\u3001PIP\u95a2\u7bc0\u3001\u304a\u3088\u3073\u7b2c1 CMC\u95a2\u7bc0\u306b\u304a\u3051\u308b\u8edf\u9aa8\u4e0b\u9aa8\u3073\u3089\u3093\u306e\u6709\u7121\u306b\u3064\u3044\u3066\u3082\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"544\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-24-800x544.png\" alt=\"\" class=\"wp-image-1643\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-24-800x544.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-24-400x272.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-24-767x522.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-24.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Ann Rheum Dis. 1957 Dec;16(4):494\u2013502. doi: 10.1136\/ard.16.4.494\u3000Radiological Assessment of Osteo-ArthrosisJ H Kellgren, J S Lawrence \u3000\u3088\u308a\u629c\u7c8b\u4e00\u90e8\u5909\u66f4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b0\u30ec\u30a4\u30c9\uff12\u4ee5\u4e0a\u3092\u30ec\u30f3\u30c8\u30b2\u30f3\u306b\u3088\u308bHOA\u3068\u8003\u3048\u3001\u30b0\u30ec\u30a4\u30c9\uff13\u3092\u91cd\u75c7HOH\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u6d78\u98df\u306e\u3042\u308b\u30b0\u30eb\u30fc\u30d7\u3092EHOA\u3068\u3057\u3066\u5206\u985e\u3057\u3066\u3044\u307e\u3059\u3002\u4fee\u6b63KL\u5206\u985e\u3067\u306f\u30b0\u30ec\u30a4\u30c9\uff10\uff08\u6b63\u5e38\uff09\u30b0\u30ec\u30a4\u30c9\uff11\uff08\u5909\u6027\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\uff09\u306e\u5206\u985e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5c02\u9580\u5bb6\u306b\u304a\u3053\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u79c1\u81ea\u8eab\u30b0\u30ec\u30a4\u30c9\uff10\u3068\uff11\u306e\u533a\u5225\u306f\u307b\u3068\u3093\u3069\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u3067\u306f\u3001KL\u30b0\u30ec\u30a4\u30c9\uff13\u4ee5\u4e0a\u3092\u91cd\u75c7\u3068\u5b9a\u7fa9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u9aa8\u3073\u3089\u3093\u306b\u3064\u3044\u3066\u306e\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Gull-wing erosions\u3068\u3044\u308f\u308c\u308b\u30ab\u30e2\u30e1\u304c\u7ffc\u3092\u5e83\u3052\u305f\u3088\u3046\u306b\u307f\u3048\u308b\u4fb5\u98df\u50cf\u3084\u3001 Sawtooth erosions\u3068\u3044\u3046\u3001\u306e\u3053\u304e\u308a\u306e\u6b6f\u306e\u3088\u3046\u306b\u307f\u3048\u308b\u9aa8\u3073\u3089\u3093\u50cf\u304c\u5178\u578b\u7684\u306a\u50cf\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-25-800x534.png\" alt=\"\" class=\"wp-image-1644\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-25-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-25-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-25-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-25.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">seagull\u3000wing\u3000patterns\uff08\u5de6\u56f3\uff09\u3068saw\u3000tooth\u3000pattern\uff08\u53f3\u56f3\uff09<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">MB Orthop\uff0e29\uff0811\uff09\uff1a31\uff0d36\uff0c2016\u5916\u6765\u3067\u3088\u304f\u8a3a\u308b\u624b\u5916\u79d1\u75be\u60a3\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0, \u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\u3000\u5efa\u90e8\u5c06\u5e83\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbOsteoarthritis Cartilage. 2007:15 Suppl A:A1-56. doi: 10.1016\/j.joca.2006.11.009.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Atlas of individual radiographic features in osteoarthritis, revised\u3000R D Altman, G E Gold<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbAnn Rheum Dis. 1957 Dec;16(4):494\u2013502. doi: 10.1136\/ard.16.4.494\u3000Radiological Assessment of Osteo-ArthrosisJ H Kellgren, J S Lawrence<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5e73\u5747\u5e74\u9f6265\uff0e6\u6b73\u306e\u65e5\u672c\u4eba\u306e\u624b\u6307\u306e\u5909\u5f62\u767a\u751f\u500b\u6240\u306b\u3064\u3044\u3066\u306e\u8abf\u67fb\u7d50\u679c\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08ROAD\u3000study\uff09<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u8abf\u67fb\u7d50\u679c<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u9060\u4f4d\u6307\u9593\u95a2\u7bc0(DIP)\u306eOA\u304c\u6700\u3082\u9ad8\u304f\u767a\u751f\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-26-800x533.png\" alt=\"\" class=\"wp-image-1645\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-26-800x533.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-26-400x266.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-26-767x511.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-26.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">ROAD\u3000study\u3088\u308a\u629c\u7c8b\u4e00\u90e8\u5909\u66f4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u306e\u56f3\u306f\u3001\u30ec\u30f3\u30c8\u30b2\u30f3\u4e0a\u3067\u8a3a\u65ad\u3055\u308c\u305f\u3001\u624b\u95a2\u7bc0\u306e\u5909\u5f62\u306e\u30d1\u30fc\u30bb\u30f3\u30c8\uff08\uff05\uff09\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u5de6\u304c\u7537\u6027\u3001\u53f3\u304c\u5973\u6027\u3067\u767a\u898b\u3055\u308c\u305f\u305d\u308c\u305e\u308c\u306e\u95a2\u7bc0\u3067\u306e\u5909\u5f62\u5272\u5408\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc01\u3064\u4ee5\u4e0a\u306bKL2\u4ee5\u4e0a\u306eHOA\u304c\u8a8d\u3081\u3089\u308c\u305f\u5272\u5408\u306f\u3001\u5408\u8a08\u3067\u300191.5\uff05\u3067\u3057\u305f\u3002\u7537\u6027\u306f\u300189.9%\u3001\u5973\u6027\u306f\u300192.3%\u3067\u3001\u5e74\u9f62\u4e0a\u6607\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"373\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-27-800x373.png\" alt=\"\" class=\"wp-image-1646\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-27-800x373.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-27-400x186.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-27-766x357.png 766w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-27.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">ROAD\u3000study\u3088\u308a\u629c\u7c8b\u4e00\u90e8\u5909\u66f4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5973\u6027\u306e\u307f\u306a\u3089\u305a\u3001\u7537\u6027\u306b\u3082\u6709\u75c5\u7387\u306f\u5e74\u9f62\u3068\u3068\u3082\u306b\u52b9\u7387\u306b\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"516\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-28-800x516.png\" alt=\"\" class=\"wp-image-1648\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-28-800x516.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-28-400x258.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-28-767x495.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-28.png 882w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">KL\u30b0\u30ec\u30fc\u30c9\u22673\u3068\u9aa8\u3073\u3089\u3093\uff08erosion\uff09\u306e\u4e21\u65b9\u304c\u63e1\u529b\u4f4e\u4e0b\u3068\u624b\u306e\u75db\u307f\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u7279\u306bDIP\u304a\u3088\u3073\u6bcd\u6307CM\u95a2\u7bc0\u306e\u91cd\u5ea6\u306eOA\u304c\u624b\u306e\u75db\u307f\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HOA\u306e\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3084\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\u306e\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u3068\u3057\u3066\u5e74\u9f62\u3001\u6027\u5225\u3001\u5bb6\u65cf\u6b74\u3001\u9ad8\u3044\u9aa8\u5bc6\u5ea6\u3001\u80a5\u6e80\u3001\u6a5f\u68b0\u7684\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u3082\u91cd\u8981\u306a\u30d5\u30a1\u30af\u30bf\u30fc\u306f\u5e74\u9f62\u3067\u300150\u6b73\u4ee5\u964d\u3067\u767a\u75c7\u7387\u306f\u6025\u6fc0\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u91cd\u8981\u306a\u30d5\u30a1\u30af\u30bf\u30fc\u3068\u3057\u3066\u5973\u6027\u306f\u3001\u672c\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u30011\u6b73\u5e74\u9f62\u3092\u7d4c\u308b\u3054\u3068\u306e\u767a\u751f\u7387\u306f\u3001\u7537\u6027\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u305b\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbAnn Rheum Dis. Author manuscript; available in PMC: 2013 Dec 19.Published in final edited form as: Ann Rheum Dis. 2011 May 27;70(9):10.1136\/ard.2011.150078. doi: 10.1136\/ard.2011.150078\u3000Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ida K Haugen, Martin Englund, Piran Aliabadi, Jingbo Niu, Margaret Clancy, Tore K Kvien, David T Felson<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbMod Rheumatol. 2016 Sep;26(5):767-73. doi: 10.3109\/14397595.2015.1130673. Epub 2016 Feb 16.\u3000Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rie Kodama, Shigeyuki Muraki, Hiroyuki Oka, Toshiko Iidaka, Masatoshi Teraguchi, Ryohei Kagotani, Yoshiki Asai, Munehito Yoshida, Yutaka Morizaki, Sakae Tanaka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Noriko Yoshimura<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u3073\u3089\u3093\u6027\uff08\u7834\u58ca\u304c\u9aa8\u307e\u3067\u4fb5\u98df\u3057\u3066\u3044\u308b\u3082\u306e\uff09\u306e\u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\u3000Erosive hand osteoarthritis\uff08\u4ee5\u4e0b\u3001EHOH\uff09\u306b\u3064\u3044\u3066<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3073\u3089\u3093\u6027HOA\u306f\u3001\u6d78\u98df\u306e\u306a\u3044\u975e\u3073\u3089\u3093\u6027HOA\uff08\u95a2\u7bc0\u88c2\u3052\u304d\u306e\u72ed\u5c0f\u5316\u3084\u9aa8\u306e\u786c\u5316\u50cf\u306e\u307f\uff09\u3088\u308a\u75c7\u72b6\u304c\u91cd\u304f\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306e\u4e9c\u578b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7a81\u7136DIP\u3084PIP\u95a2\u7bc0\u306b\u75bc\u75db\u3068\u816b\u8139\u304c\u751f\u3058\u3001\u6ed1\u819c\u708e\u3092\u4f34\u3046\u3082\u306e\u306e\u3001\u5168\u8eab\u6027\u708e\u75c7\u53cd\u5fdc\u306f\u73fe\u308c\u306b\u304f\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3073\u3089\u3093\u6027\u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\u306e\u30ec\u30f3\u30c8\u30b2\u30f3\u50cf\u3067\u306f\u9aa8\u68d8\u3084\u9aa8\u786c\u5316\u90e8\u4f4d\u304c\u307f\u3089\u308c\u3001\u95a2\u7bc0\u9762\u306e\u4e2d\u592e\u306b\u3073\u3089\u3093\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u6307\u7bc0\u95a2\u7bc0\u306e\u5909\u5f62\u304c\u9032\u884c\u3059\u308b\u3068\u6307\u7bc0\u9aa8\u304c\u6ce2\u3092\u3046\u3063\u305f\u3088\u3046\u306a\u5909\u5f62\u3084DIP\u95a2\u7bc0\u306e\u4e9c\u8131\u81fc\u304c\u7279\u5fb4\u7684\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"283\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-29-800x283.png\" alt=\"\" class=\"wp-image-1649\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-29-800x283.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-29-400x141.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-29-767x271.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-29.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5de6\u306f\u521d\u671f\u306eEHOH\u50cf\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u53f3\u306f\u9032\u884c\u3057\u305fEHOH\u50cf\u3092\u793a\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nat Rev Rheumatol. 2022 Mar;18(3):171-183. doi: 10.1038\/s41584-021-00747-3. Epub 2022 Feb 1.Erosive hand osteoarthritis: latest findings and outlookMarta Favero, Elisa Belluzzi, Augusta Ortolan, Mariagrazia Lorenzin, Francesca Oliviero, Andrea Doria , Carla R Scanzello , Roberta Ramonda \u3088\u308a\u629c\u7c8b\u8a18\u8f09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6307\u5148\u306e\u786c\u76f4\u3001\u2605\u5370\u306e\u90e8\u5206\u306f\u3001\u9aa8\u68d8\u306e\u6210\u9577\u306b\u3088\u308a\u95a2\u7bc0\u304c\u81a8\u5f35\u3057\u3066\u307f\u3048\u307e\u3059\u3002\u3084\u3084\u6307\u5148\u306e\u95a2\u7bc0\u306f\u8d64\u304f\u3001\u884c\u4f8b\u3067\u306f\u4eba\u5dee\u3057\u6307\u306e\u4e26\u3073\u304c\u305a\u308c\u3066\u3044\u308b\uff08\u7dd1\u306e\u7dda\uff09\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">EHOH\u306e\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f\u306b\u3064\u3044\u3066<\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"195\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-30-800x195.png\" alt=\"\" class=\"wp-image-1650\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-30-800x195.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-30-400x98.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-30-767x187.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-30.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Nat Rev Rheumatol. 2022 Mar;18(3):171-183. doi: 10.1038\/s41584-021-00747-3. Epub 2022 Feb 1.Erosive hand osteoarthritis: latest findings and outlookMarta Favero, Elisa Belluzzi, Augusta Ortolan, Mariagrazia Lorenzin, Francesca Oliviero, Andrea Doria , Carla R Scanzello , Roberta Ramonda \u3088\u308a\u629c\u7c8b\u8a18\u8f09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ec\u30f3\u30c8\u30b2\u30f3\u306b\u304a\u3044\u3066\u306f\u3001\u5de6\u7aef\u306e\u5199\u771f\u3067\u306f\uff08\u8d64<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">\u2605<\/mark>\u5370\uff09\u90e8\u5206\u306b\u95a2\u7bc0\u88c2\u3052\u304d\u306e\u72ed\u5c0f\u5316\u3001\uff08\u9ec4\u8272<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-amber-color\">\u2605<\/mark>\u5370\uff09\u90e8\u5206\u306e\u95a2\u7bc0\u304c\u4e2d\u5fc3\u90e8\u5206\u304c\u5909\u5f62\u3057\u95a2\u7bc0\u304c\u878d\u5408\u3057\u3066\u307f\u3048\u307e\u3059\u3002\u771f\u3093\u4e2d\u306e\u5199\u771f\uff08\u8d64<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">\u2605<\/mark>\u5370\uff09\u306f\u3001Gull-wing erosions\u3068\u3044\u308f\u308c\u308b\u30ab\u30e2\u30e1\u304c\u7ffc\u3092\u5e83\u3052\u305f\u3088\u3046\u306b\u307f\u3048\u308b\u4fb5\u98df\u50cf\u3067\u3001\u53f3\u5199\u771f\u306f\u3001 Sawtooth erosions\u3068\u3044\u3046\u3001\u306e\u3053\u304e\u308a\u306e\u6b6f\u306e\u3088\u3046\u306b\u307f\u3048\u308b\u9aa8\u3073\u3089\u3093\u50cf\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ea\u30a6\u30de\u30c1\u3068\u4e7e\u766c\u6027\u95a2\u7bc0\u708e\u3068\u75db\u98a8\u306b\u3088\u308b\u95a2\u7bc0\u5909\u5f62\u306b\u3064\u3044\u3066\u306e\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f\u3092\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"319\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-31-800x319.png\" alt=\"\" class=\"wp-image-1651\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-31-800x319.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-31-400x159.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-31-766x305.png 766w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-31.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5de6\u306e\u5199\u771f\u306f\u3001\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306e\u5199\u771f\u3067\u3059\u3002\u7b2c\u4e8c\u95a2\u7bc0\u3067\u3042\u308bPIP\u90e8\u5206\uff08\u8d64<kbd><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">\u2605<\/mark><\/kbd>\u5370\uff09\u306b\u95a2\u7bc0\u306e\u5909\u5f62\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u4eba\u5dee\u3057\u6307\u306eMP\u95a2\u7bc0\u90e8\u5206\u306b\u4e9c\u8131\u81fc\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u771f\u3093\u4e2d\u306e\u5199\u771f\u306f\u3001\u4e7e\u766c\u6027\u95a2\u7bc0\u708e\u306e\u60a3\u8005\u306e\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f\u3067\u3059\u304c\u3001\u5c0f\u6307\u306e\u5148\u7aef\u306eDIP\u95a2\u7bc0\uff08\u767d\u77e2\u5370\uff09\u306b\u3001\u8fba\u7e01\u306b\u5f37\u304f\u9aa8\u306e\u4fb5\u98df\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u9ec4\u8272\u7dda\u90e8\u5206\u306f\u3001\u5199\u771f\u3067\u308f\u304b\u308a\u306b\u304f\u3044\u3067\u3059\u304c\u30011\u672c\u306e\u6307\u5168\u4f53\u304c\u30bd\u30fc\u30bb\u30fc\u30b8\u306e\u3088\u3046\u306b\u816b\u308c\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\uff08\u6307\u708e\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53f3\u56f3\u306f\u3002\u75db\u98a8\u306b\u3088\u308b\u3082\u306e\u3067\u3001\u75db\u98a8\u7d50\u7bc0\u306b\u3088\u3063\u3066\u95a2\u7bc0\u5305\u304c\u81a8\u3089\u307f\u3001\u9aa8\u3073\u3089\u3093\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ea\u30a6\u30de\u30c1\u3068EHOA\u306e\u767a\u75c7\u90e8\u4f4d\u306e\u9055\u3044\u306b\u3064\u3044\u3066<\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-32-800x534.png\" alt=\"\" class=\"wp-image-1652\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-32-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-32-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-32-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-32.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">https:\/\/www.med.osaka-u.ac.jp\/pub\/imed3\/disease\/d-immu02-4.html \u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\uff5c\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 \u547c\u5438\u5668\u30fb\u514d\u75ab\u5185\u79d1\u5b66\u3088\u308a\u629c\u7c8b\u3000\u4e00\u90e8\u52a0\u7b46\u5909\u66f4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u306a\u3063\u3066\u3044\u308b\u90e8\u5206\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u767a\u75c7\u90e8\u4f4d\u306b\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002\u3073\u3089\u3093\u306f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u306f\u8fba\u7e01\u3001\u30d6\u30e9\u30f3\u6027\u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7EHOA\u3067\u306f\u4e2d\u5fc3\u90e8\u5206\u306b\u304a\u3053\u308a\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u3068\u30ea\u30a6\u30de\u30c1\u306f\u5de6\u53f3\u5bfe\u79f0\u306b\u767a\u751f\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30ea\u30a6\u30de\u30c1\u3067\u306fDIP\u95a2\u7bc0\u304c\u4fb5\u3055\u308c\u308b\u3053\u3068\u306f\u3042\u307e\u308a\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">EHOA\u306f\u6bd4\u8f03\u7684\u7a00\u306a\u75be\u60a3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u65e5\u672c\u4eba\u306e\u8abf\u67fb\u306b\u304a\u3044\u3066EHOA\u306e\u5272\u5408\u306f\u3001\u5168\u4f53\u30674.2\uff05\u3067\u3042\u308a\u5185\u8a33\u306f\u7537\u6027 2.2\uff05 \u3001\u5973\u60275.3\uff05\u3067\u5973\u6027\u306e\u65b9\u304c\u591a\u3044\u7d50\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3057\u305f\uff08P\uff1d 0.0048\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kwok et al. (2011)\u306e3,430 \u4eba\u3092\u8abf\u3079\u305f\u8abf\u67fb\u3067\u306f\u30011,916\u4eba\u304c\u3001\u30ec\u30f3\u30c8\u30b2\u30f3\u4e0a\u306eOA\u3068\u8a3a\u65ad\u3055\u308c\u3001\u305d\u306e\u4e2d\u3067\u75c7\u72b6\u306e\u3042\u308b\u4eba\u306f371\u4eba\u3067EHOA\u306f\u30ec\u30f3\u30c8\u30b2\u30f3\u4e0aOA\u3068\u8a3a\u65ad\u3055\u308c\u305f\u4eba\u306e5.0\uff05\u3067\u3001\u75c7\u72b6\u306e\u3042\u308b\u4eba\u306e\u4e2d\u3067\u306f10\uff05\u3067\u3057\u305f\u3002\u307e\u305f\u3001Marshall et al. (2013)\u306e6,306\u4eba\u306e\u8abf\u67fb\u3067\u306f\u3001 1,076\u4eba\u304c\u624b\u306eOA\u75c7\u72b6\u3092\u6301\u3063\u3066\u304a\u308a\u3053\u306e\u3046\u3061EHOA\u306f\u30014.8\uff05\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e\u30fb\u8cc7\u6599<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbNat Rev Rheumatol. 2022 Mar;18(3):171-183. doi: 10.1038\/s41584-021-00747-3. Epub 2022 Feb 1.Erosive hand osteoarthritis: latest findings and outlook\u3000Marta Favero, Elisa Belluzzi, Augusta Ortolan, Mariagrazia Lorenzin, Francesca Oliviero, Andrea Doria, Carla R Scanzello, Roberta Ramonda<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbhttps:\/\/www.med.osaka-u.ac.jp\/pub\/imed3\/disease\/d-immu02-4.html \u5909\u5f62\u6027\u624b\u95a2\u7bc0\u75c7\uff5c\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 \u547c\u5438\u5668\u30fb\u514d\u75ab\u5185\u79d1\u5b66<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbhttps:\/\/kompas.hosp.keio.ac.jp\/disease\/000611\/?utm_source=openai \u4e7e\u766c\u6027\u95a2\u7bc0\u708e\uff08psoriatic arthritis: PsA\uff09 | KOMPAS \u2013 \u6176\u61c9\u7fa9\u587e\u5927\u5b66\u75c5\u9662 \u533b\u7642\u30fb\u5065\u5eb7\u60c5\u5831\u30b5\u30a4\u30c8<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75bc\u75db\u7ba1\u7406\u306b\u3064\u3044\u3066<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6cbb\u7642<\/h3>\n\n\n\n<p 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class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"507\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-33-800x507.png\" alt=\"\" class=\"wp-image-1653\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-33-800x507.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-33-400x254.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-33-767x486.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-33.png 885w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">\u6cbb\u7642\u65b9\u6cd5\u306b\u8a18\u8f09\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u3068\u63a8\u5968\u5ea6\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u25ce\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u786b\u9178\uff081b A\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HOA\u306b\u5bfe\u3057\u3066\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u786b\u9178\u5869\u304c\u3001\u6a5f\u80fd\u3068\u75be\u75db\u306e\u6539\u5584\u304c\u5f97\u3089\u308c\u305f\u3068\u3044\u3046\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u63a8\u5968\u5ea6\u306fA\u3067\u3059\u304c\u3001\u63a8\u5968\u3068\u3044\u3046\u3088\u308a\u4f7f\u7528\u3057\u3066\u3082\u3088\u3044\u3068\u3044\u3046\u611f\u3058\u3067\u8ad6\u6587\u4e2d\u306b\u306f\u8a18\u8f09\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u82f1\u56fd\u306e\u516c\u7684\u6a5f\u95a2 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class=\"wp-block-paragraph\">\u25cf\u5f93\u6765\u306e\u30ea\u30a6\u30de\u30c1\u88fd\u5264\u3084\u751f\u7269\u5b66\u7684\u6297\u30ea\u30a6\u30de\u30c1\u5264\u3092\u4f7f\u7528\u3059\u308b\u3079\u304d\u3067\u306f\u306a\u3044\u3068\u3057\u3066\u3044\u307e\u3059\uff081a A \uff09\u3002\u4f4e\u7528\u91cf\u306e\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u9577\u671f\u4f7f\u7528\u30822018\u5e74\u6642\u70b9\u3067\u306f\u4e0d\u900f\u660e\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u95a2\u7bc0\u5185\u6ce8\u5c04<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u25ce\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u95a2\u7bc0\u5185\u6ce8\u5c04\uff08lb A\uff09\u4e00\u822c\u306b\u884c\u3046\u3079\u304d\u3067\u306f\u306a\u3044\u304c\u3001\u75db\u307f\u304c\u5f37\u3044\u5834\u5408\u306f\u8003\u616e\u3057\u3066\u3082\u3088\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u624b\u8853<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u25ce\u75bc\u75db\u7de9\u548c\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u306b\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002\uff085 D\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u624b\u8853\u306a\u306e\u3067\u3001\u30e9\u30f3\u30c0\u30e0\u6bd4\u8f03\u8a66\u9a13\u306a\u3069\u306f\u4e0d\u53ef\u80fd\u3067\u3059\u3057\u3001\u5c02\u9580\u5bb6\u306e\u610f\u898b\u30ec\u30d9\u30eb\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u65e5\u672c\u3067\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\u6cbb\u7642\u65b9\u6cd5\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\u975e\u85ac\u7269\u7642\u6cd5<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u672c\u7684\u306b\u306f\u5bfe\u75c7\u7642\u6cd5\u304c\u4e2d\u5fc3\u3067\u3001\u30c6\u30fc\u30d4\u30f3\u30b0\u3092\u5dfb\u304f\u3060\u3051\u3067\u75c7\u72b6\u304c\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3082\u591a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-34-800x534.png\" alt=\"\" class=\"wp-image-1654\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-34-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-34-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-34-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-34.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u3078\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u30c6\u30fc\u30d4\u30f3\u30b0\u3000\u3000\u3000\u3000\u3000\u3000\u30b9\u30ea\u30fc\u30a8\u30e0 \u30b3\u30fc\u30d0\u30f3 \u81ea\u7740\u6027\u4f38\u7e2e\u5305\u5e2f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5074\u65b9\u4e0d\u5b89\u5b9a\u6027\u306e\u5f37\u3044\u5834\u5408\u306f\u826f\u3044\u9069\u5fdc\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u753b\u50cf<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u3000Vol\uff0e45\u3000No\uff0e11\uff082024\uff0e11\uff09 1191\uff0d1197\u3000\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306e\u75db\u307f\u3000\u4e09\u6d66\u4fca\u6a39\u3000\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\uff08\u79cb\u306e\u7279\u5225\u4fa1\u683c\uff09\u30b9\u30ea\u30fc\u30a8\u30e0 \u30b3\u30fc\u30d0\u30f3 \u81ea\u7740\u6027\u4f38\u7e2e\u5305\u5e2f \u30b9\u30e2\u30fc\u30eb\u30fb\u30d1\u30c3\u30af 25mm\u00d74.5m 1581SP &#8211; \u30a2\u30b9\u30af\u30eb\u3000\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4fdd\u5b58\u7642\u6cd5\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u3001\u75bc\u75db\u304c\u5f37\u3044\u3068\u304d\u306b\u306f\u30b7\u30fc\u30cd\u56fa\u5b9a\u306a\u3069\u306b\u3088\u3063\u3066\u3001\u95a2\u7bc0\u306e\u5b89\u9759\u52a0\u7642\u304c\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-35-800x534.png\" alt=\"\" class=\"wp-image-1655\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-35-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-35-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-35-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-35.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">\u5de6\uff09\u6bcd\u6307CM\u95a2\u7bc0\u75c7\u306b\u5bfe\u3059\u308b\u88c5\u5177\u3000\u3000\u3000\u3000\u3000\u3000\u53f3\uff09\u3078\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306b\u5bfe\u3059\u308b\u88c5\u5177<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u7406\u5b66\u7642\u6cd5\u300037\u5dfb4\u53f7\u30002020\u5e744\u6708357\u2014365\u3000\u52a0\u9f62\u306b\u4f34\u3046\u904b\u52d5\u5668\u306e\u5909\u5316\u3068\u7406\u5b66\u7642\u6cd5\u3000\u7530\u3000\u5cf6\u3000\u8cb4\u3000\u6587\u3000\u3000\u9152\u3000\u4e95\u3000\u662d\u3000\u5178\u3000\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u904b\u52d5\u7642\u6cd5<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u904b\u52d5\u7642\u6cd5\u306f\u5b89\u5168\u3067\u526f\u4f5c\u7528\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u75be\u75db\u306e\u306a\u3044\u6a5f\u80fd\u7684\u53ef\u52d5\u57df\u306e\u62e1\u5927\u30fb\u7b4b\u529b\u7dad\u6301\u304c\u5927\u5207\u3067\u3059\u3002\u7269\u3092\u5f37\u304f\u63b4\u3080\u52d5\u4f5c\u3084\u75db\u307f\u306e\u51fa\u3084\u3059\u3044\u52d5\u4f5c\u3092\u5236\u9650\u3059\u308b\u4e00\u65b9\u3067\u3001\u95a2\u7bc0\u304c\u304b\u305f\u304f\u306a\u3089\u306a\u3044\u3088\u3046\u306b\u75db\u307f\u306e\u306a\u3044\u7bc4\u56f2\u3067\u30b9\u30c8\u30ec\u30c3\u30c1\u3092\u884c\u3044\u3001\u65e5\u5e38\u751f\u6d3b\u52d5\u4f5c\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u3081\u3056\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e\u30fb\u8cc7\u6599<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbMBMed\u3000Reha\u3000No\uff0e244\uff1a58\uff0d63\uff0c2020\u7279\u96c6\uff0f\u624b\u5916\u79d1\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u8a3a\u7642\u3000Heberden\u7d50\u7bc0\u30fbBouchard\u7d50\u7bc0\u306e\u6cbb\u7642\u3068\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u3000\u6797\u539f\u96c5\u5b50\u3000\u677e\u4e0b\u4e45\u7f8e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u3000Vol\uff0e45\u3000No\uff0e11\uff082024\uff0e11\uff09 1191\uff0d1197\u3000\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306e\u75db\u307f\u3000\u4e09\u6d66\u4fca\u6a39<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbhttps:\/\/www.kitasato-u.ac.jp\/hokken-hp\/visitor\/office_visit\/heberdens.html#anc04\u3000\u3078\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3001\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\uff5c\u5317\u91cc\u5927\u5b66\u5317\u91cc\u7814\u7a76\u6240\u75c5\u9662\uff08\u6771\u4eac\u90fd\u6e2f\u533a\uff09<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u85ac\u7269\u7642\u6cd5<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">NSAID\uff53<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30e1\u30a4\u30f3\u3068\u3057\u3066\u306f\u3001NSAIDs\u306e\u5916\u7528\u85ac\u3084\u8cbc\u4ed8\u5264\u3001\u5185\u670d\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3082\u8003\u616e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u306b\u8ff0\u3079\u305f\u65b9\u6cd5\u4ee5\u5916\u306b\u30012019\u5e74\u30a2\u30e1\u30ea\u30ab\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\/\u95a2\u7bc0\u708e\u8ca1\u56e3\u306e\u624b\u30fb\u80a1\u95a2\u7bc0\u30fb\u819d\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u7ba1\u7406\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3001\u30c7\u30e5\u30ed\u30ad\u30bb\u30c1\u30f3\u3001\u30c8\u30e9\u30de\u30c9\u30fc\u30eb\u306a\u3069\u306e\u85ac\u7269\u4f7f\u7528\u3084\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5\u3084\u937c\u7078\u3001\u6e29\u71b1\u3084\u51b7\u5374\u7642\u6cd5\u306a\u3069\u306e\u8003\u616e\u306b\u3064\u3044\u3066\u306e\u8a18\u8f09\u304c\u3042\u308a\u307e\u3057\u305f\uff08\uff11\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u30a8\u30af\u30aa\u30fc\u30eb\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">EULAR\u306e\u30ea\u30b3\u30e1\u30f3\u30c7\u30fc\u30b7\u30e7\u30f3\u306b\u306f\u8868\u8a18\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u30012025\u5e74\u3001\u524d\u5411\u304d\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76\u30673\u304b\u6708\u306e\u6295\u4e0e\u3067\u75bc\u75db\u306b\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff08\uff12\uff09\u3002\u307e\u305f\u3001\u5973\u6027\u304c\u624b\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u3068\u30a8\u30af\u30aa\u30fc\u30eb\u7523\u751f\u30ec\u30d9\u30eb\u306e\u9593\u306b\u6709\u610f\u306a\u76f8\u95a2\u304c\u3042\u308b\u3068\u3044\u3046\u5831\u544a\uff08\uff13\uff09\u3082\u3042\u308a\u307e\u3059\u3002\u672c\u90a6\u3067\u306f\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3084\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\u306b\u5bfe\u3059\u308b\u75c7\u72b6\u7de9\u548c\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\uff11\uff092019 American College of Rheumatology\/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sharon L Kolasinski \u3000et al\uff0e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\uff12\uff09Cureus. 2025 Jul 15;17(7):e88013. doi: 10.7759\/cureus.88013. eCollection 2025 Jul.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Effects of Equol on Hand Osteoarthritis in Perimenopausal Women: A Pilot Study<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Takashi Shimoe, Hiroshi Hashizume, Hiroyuki Oka, Tadafumi Susa, Tomomi Ueno, Shigeto Uchiyama, Yasushi Toge, Mito Hayashi, Yoji Kitano, Hiroshi Yamada<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\uff13\uff09J Orthop Sci<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">. 2025 Jan;30(1):91-95. doi: 10.1016\/j.jos.2024.02.001. Epub 2024 Feb 14.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Equol production capability and family history as risk factors for hand osteoarthritis in menopausal and postmenopausal women. Cross-sectional study<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yuichi Hirase , Arisa Okubo<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u75c7\u72b6\u304c\u5f37\u304f\u65e5\u5e38\u751f\u6d3b\u306b\u652f\u969c\u304c\u51fa\u308b\u5834\u5408\u306f\u624b\u8853\u304c\u884c\u308f\u308c\u307e\u3059\u3002<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u624b\u8853\u306b\u3064\u3044\u3066\u4e0b\u306b\u8a18\u8f09\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7c98\u6db2\u56a2\u816b\uff08\u30df\u30e5\u30fc\u30ab\u30b9\u30b7\u30b9\u30c8\uff1aDIP\u95a2\u7bc0\u3084\u6bcd\u6307IP\u95a2\u7bc0\u306b\u767a\u751f\u3059\u308b\u30ac\u30f3\u30b0\u30ea\u30aa\u30f3\uff09\u306b\u5bfe\u3057\u3066\u611f\u67d3\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u7a7f\u523a\u5438\u5f15\u3092\u884c\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u518d\u767a\u4f8b\u306a\u3069\u306b\u5bfe\u3057\u3066\u306f\u3001\u4e0b\u8a18\u306e\u3088\u3046\u306a\u80cc\u5074\u95a2\u7bc0\u5305\u5207\u9664\uff0b\u9aa8\u68d8\u5207\u9664\u306b\u3088\u308b\u6cbb\u7642\u3082\u5b9f\u65bd\u3055\u308c\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"387\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-36-800x387.png\" alt=\"\" class=\"wp-image-1656\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-36-800x387.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-36-400x194.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-36-766x371.png 766w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-36.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">MB\u3000Orthop\uff0e35\uff084\uff09\uff1a7\uff0d11\uff0c2022\u7279\u96c6\u3000\u5973\u6027\u306b\u3088\u304f\u307f\u308b\u624b\u75be\u60a3\u3000\u624b\u6307\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\uff08\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3092\u4e2d\u5fc3\u306b\uff09\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u3000\u7530\u4e2d\u3000\u5b8f\u660c\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u722a\u306b\u767a\u751f\u3057\u305f\u7c98\u6db2\u56a2\u816b\uff08\u30df\u30e5\u30fc\u30ab\u30b9\u30b7\u30b9\u30c8\uff09\u306e\u6cbb\u7642\u306b\u3064\u3044\u3066<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-37-800x534.png\" alt=\"\" class=\"wp-image-1657\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-37-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-37-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-37-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-37.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">MB\u3000Orthop\uff0e29\uff0811\uff09\uff1a31\uff0d36\uff0c2016\u7279\u96c6\u3000\u5916\u6765\u3067\u3088\u304f\u8a3a\u308b\u624b\u5916\u79d1\u75be\u60a3\u3000\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\uff0c\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\u3000\u5efa\u90e8\u3000\u5c06\u5e83\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9aa8\u68d8\u9664\u53bb\u304c\u5b9f\u65bd\u3055\u308c\u3001\u7c98\u6db2\u56a2\u816b\uff08\u30df\u30e5\u30fc\u30ab\u30b9\u30b7\u30b9\u30c8\uff1a\u4e0a\u5199\u771f\uff09\u306b\u5bfe\u3057\u3001\u722a\u306e\u5909\u5f62\u304c\u6539\u5584\uff08\u4e0b\u5199\u771f\uff09\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u95a2\u7bc0\u56fa\u5b9a\u3068\u95a2\u7bc0\u5f62\u6210\u8853\u3084\u4eba\u5de5\u95a2\u7bc0\u7f6e\u63db\u8853\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5909\u5f62\u3084\u95a2\u7bc0\u4e0d\u5b89\u5b9a\u6027\u304c\u5927\u304d\u3044\uff08\u919c\u5f62\uff09\u5834\u5408\u3084\u75bc\u75db\u304c\u5f37\u3044\u5834\u5408\u306b\u5bfe\u3057\u3066\u306f\u95a2\u7bc0\u56fa\u5b9a\u8853\u3084\u4eba\u5de5\u95a2\u7bc0\u8853\u304c\u8003\u616e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"403\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-38-800x403.png\" alt=\"\" class=\"wp-image-1658\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-38-800x403.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-38-400x201.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-38-767x386.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-38.png 886w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">MB\u3000Orthop\uff0e35\uff084\uff09\uff1a7\uff0d11\uff0c2022\u7279\u96c6\u3000\u5973\u6027\u306b\u3088\u304f\u307f\u308b\u624b\u75be\u60a3\u3000\u624b\u6307\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\uff08\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3092\u4e2d\u5fc3\u306b\uff09\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u3000\u7530\u4e2d\u3000\u5b8f\u660c\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c\u4e00\u95a2\u7bc0\u306e\u56fa\u5b9a\u306f\u3001\u6a5f\u80fd\u7684\u306b\u5927\u304d\u306a\u969c\u5bb3\u3068\u306a\u308b\u3053\u3068\u306f\u5c11\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\u306e\u3088\u3046\u306a\u7b2c\u4e8c\u95a2\u7bc0\u306e\u5834\u5408\u306f\u3001\u9593\u63a5\u306e\u53ef\u52d5\u304c\u6e29\u5b58\u3055\u308c\u308b\u95a2\u7bc0\u5f62\u6210\u8853\u3084\u4eba\u5de5\u95a2\u7bc0\u7f6e\u63db\u8853\u304c\u8003\u616e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-39-800x534.png\" alt=\"\" class=\"wp-image-1659\" style=\"width:800px;height:auto\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-39-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-39-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-39-767x512.png 767w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-39.png 884w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">\u7b2c\u4e8c\u95a2\u7bc0\u306e\u4eba\u5de5\u95a2\u7bc0\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u7406\u5b66\u7642\u6cd5\u300037\u5dfb4\u53f7\u30002020\u5e744\u6708357\u2014365\u3000\u52a0\u9f62\u306b\u4f34\u3046\u904b\u52d5\u5668\u306e\u5909\u5316\u3068\u7406\u5b66\u7642\u6cd5\u3000\u7530\u3000\u5cf6\u3000\u8cb4\u3000\u6587\u3000\u3000\u9152\u3000\u4e95\u3000\u662d\u3000\u5178\u3000\u3088\u308a\u629c\u7c8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbAnn Rheum Dis. 2019 Jan;78(1):16-24. doi: 10.1136\/annrheumdis-2018-213826. Epub 2018 Aug 28.2018 update of the EULAR recommendations for the management of hand osteoarthritis Margreet Kloppenburg, F\u00e9line Pb Kroon, Francisco J Blanco, Michael Doherty, Krysia S Dziedzic, Elsie Greibrokk, Ida K Haugen, Gabriel Herrero-Beaumont, Helgi Jonsson, Ingvild Kjeken , Emmanuel Maheu, Roberta Ramonda, Marco Jpf Ritt, Wilma Smeets, Josef S Smolen, Tanja A Stamm, Zoltan Szekanecz, Ruth Wittoek, Loreto Carmona<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbMB\u3000Orthop\uff0e35\uff084\uff09\uff1a7\uff0d11\uff0c2022\u7279\u96c6\u3000\u5973\u6027\u306b\u3088\u304f\u307f\u308b\u624b\u75be\u60a3\u3000\u624b\u6307\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\uff08\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u3092\u4e2d\u5fc3\u306b\uff09\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u3000\u7530\u4e2d\u3000\u5b8f\u660c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u3000Vol\uff0e45\u3000No\uff0e11\uff082024\uff0e11\uff091191-1197\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306e\u75db\u307f\u3000\u4e09\u6d66\u4fca\u6a39<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbLoco\uff08\u4e8cuRE\u3000voLIl\u3000nO\uff0e3\u30002025\u300046,47\uff08238,239\uff09\u624b\u6307\u306e\u5909\u5f62\u6027PlP\u95a2\u7bc0\u75c7\uff08\u30d6\u30b7\u30e3\u30fc\u30eb\u7d50\u7bc0\uff09\u306b\u5bfe\u3059\u308b\u4fdd\u5b58\u6cbb\u7642\u3068\u5916\u79d1\u6cbb\u7642\uff1aKnowledge\u3000Update\u3000\u5909\u5f62\u6027PIP\u95a2\u7bc0\u75c7\u306b\u5bfe\u3059\u308b\u4fdd\u5b58\u7642\u6cd5\u306e\u5185\u5bb9\u3068\u305d\u306e\u52b9\u679c\uff1a\u5b9f\u81e8\u5e8a\u306b\u3082\u3068\u3064\u304f\u30a2\u30d6\u30ed\u30fc\u30c1\u3000\u3000\u4e0b\u6c5f\u9686\u53f8<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306e\u75bc\u75db\u306e\u7d4c\u904e\u306b\u3064\u3044\u3066<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306e\u75be\u75db\u306f\u4e00\u5b9a\u671f\u9593\u306e\u7d4c\u904e\u306e\u5f8c\u306b\u7121\u75db\u3068\u306a\u308b\u3068\u3082\u8a18\u8f09\u3055\u308c\u3066\u304a\u308a\u3001\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306f\u7279\u306b\u6cbb\u7642\u3092\u8981\u3055\u306a\u3044\u75be\u60a3\u3068\u3044\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5168\u4f8b\u304c\u826f\u597d\u306a\u7d4c\u904e\u3092\u305f\u3069\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u5e73\u57476\u5e74\u306e\u7d4c\u904e\u306748\uff05\u304c\u75be\u75db\u60aa\u5316\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u3000Vol\uff0e45\u3000No\uff0e11\uff082024\uff0e11\uff091191-1197\u30d8\u30d0\u30fc\u30c7\u30f3\u7d50\u7bc0\u306e\u75db\u307f\u3000\u4e09\u6d66\u4fca\u6a39<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbAnn Rheum Dis. 2011 Jan;70(1):68-73. doi: 10.1136\/ard.2010.133017. Epub 2010 Aug 24.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">J Bijsterbosch , I Watt, I Meulenbelt, F R Rosendaal, T W J Huizinga, M Kloppenburg<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-6-800x533.jpeg\" alt=\"\" class=\"wp-image-1634\" style=\"aspect-ratio:1.4986666666666666;width:562px;height:auto\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-6-800x533.jpeg 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-6-400x267.jpeg 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-6-768x512.jpeg 768w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-6.jpeg 843w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u624b\u306e\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306b\u5bfe\u3057\u3066\u3001\u56fa\u5b9a\u65b9\u6cd5\u3084\u624b\u8853\u3092\u8003\u616e\u3059\u308b\u5834\u5408\u306f\u3001\u6574\u5f62\u5916\u79d1\u53d7\u8a3a\u3092\u304a\u52e7\u3081\u3057\u3066\u3044\u307e\u3059\u3002\u75c7\u72b6\u304c\u5f37\u304f\u3001\u30ea\u30a6\u30de\u30c1\u3084\u81a0\u539f\u75c5\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u306f\u3001\u81a0\u539f\u75c5\u5185\u79d1\u3001\u3082\u3057\u304f\u306f\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u306e\u3044\u308b\u6574\u5f62\u5916\u79d1\u306e\u5148\u751f\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3068\u3044\u3063\u305f\u6709\u52b9\u306a\u65b9\u6cd5\u304c\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u5c11\u3057\u3067\u3082\u75bc\u75db\u304c\u7de9\u548c\u3057\u751f\u6d3b\u306e\u8cea\u304c\u5411\u4e0a\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u306b\u6cbb\u7642\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u75db\u307f\u3067\u304a\u60a9\u307f\u306e\u65b9\u306e\u6765\u9662\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30af\u30ea\u30cb\u30c3\u30af\u9650\u5b9a\u8ca9\u58f2\u306e\u30a8\u30af\u30a8\u30eb\u30d7\u30c1\uff08\u30a8\u30af\u30aa\u30fc\u30eb\uff09\u306e\u8ca9\u58f2\u306f\u5f53\u9662\u306b\u3066\u3082\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uff14\uff13\uff12\uff10\u5186\/\uff11\u888b\uff08\u4e00\u304b\u6708\u5206\uff09<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-40-800x534.png\" alt=\"\" class=\"wp-image-1660\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-40-800x534.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-40-400x267.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/10\/image-40-767x512.png 767w, 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