{"id":1388,"date":"2026-08-15T18:10:26","date_gmt":"2026-08-15T09:10:26","guid":{"rendered":"https:\/\/ito-pain.com\/blog\/?p=1388"},"modified":"2026-08-15T18:16:06","modified_gmt":"2026-08-15T09:16:06","slug":"post-1388","status":"publish","type":"post","link":"https:\/\/ito-pain.com\/blog\/post-1388\/","title":{"rendered":"\u65b0\u85ac\u3000\u7247\u982d\u75db\u306e\u4e88\u9632\u85ac\u3000\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\uff08\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\uff1aatogepant\uff09\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n<p 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class=\"wp-block-heading\">\u53cd\u5fa9\u6027\u30fb\u6162\u6027\u3068\u306f\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7247\u982d\u75db\u306f\u3001\u53cd\u5fa9\u6027\u7247\u982d\u75db\uff08\u76f4\u8fd13\u30ab\u6708\u3067\u6708\u5f53\u305f\u308a\u306e\u982d\u75db\u65e5\u6570\u304c1\uff15\u65e5\u672a\u6e80\u3067\u767a\u751f\u3057\u3001\u305d\u306e\u3046\u3061\u4f55\u65e5\u304b\u304c\u7247\u982d\u75db\u306e\u5b9a\u7fa9\u3092\u6e80\u305f\u3059\u3082\u306e\uff09\u304b\u3089\u6162\u6027\u7247\u982d\u75db\uff083\u304b\u6708\u3092\u8d85\u3048\u3066\u6708\u5f53\u305f\u308a\u306e\u982d\u75db\u65e5\u6570\u304c15\u65e5\u4ee5\u4e0a\u3001\u304b\u3064\u305d\u306e8\u65e5\u4ee5\u4e0a\u304c\u7247\u982d\u75db\u306b\u3088\u308b\u3082\u306e\uff09\u3078\u9032\u884c\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7247\u982d\u75db\u306e\u6709\u75c5\u7387\u306f\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fd\u5185\u3067\u306f15\u6b73\u4ee5\u4e0a\u306e\u7247\u982d\u75db\u6709\u75c5\u7387\u306f8.4\uff05\u3067\u305d\u306e\u3046\u30615.8%\u306f\u524d\u5146\u306a\u3057\u306e\u7247\u982d\u75db\u3067\u524d\u5146\uff08\u982d\u75db\u304c\u59cb\u307e\u308b\u524d\u306b\u8eab\u4f53\u306b\u4e00\u6642\u7684\u306b\u51fa\u73fe\u3059\u308b\u75c7\u72b6\uff09\u3092\u4f34\u3046\u7247\u982d\u75db\u306f\u30012.6%\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u30593\uff09\u3002\u9ce5\u53d6\u306e\u5927\u5c71\u753a\u306e\u5168\u6210\u4eba\u4f4f\u6c11\u8abf\u67fb\u306b\u304a\u3044\u3066\u306f\u3001\u7247\u982d\u75db\u306e\u5168\u4f53\u7684\u306a\u6709\u75c5\u7387\u306f6.0%\u3067\u5973\u6027\u306f\u7537\u6027\u306b\u6bd4\u3079\u3066\u7247\u982d\u75db\u306e\u30ea\u30b9\u30af\u304c5.9\u500d\u9ad8\u3044\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u7279\u306b30\uff5e40\u6b73\u4ee3\u5973\u6027\u3067\u591a\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u30594\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u53c2\u8003\u8cc7\u6599\u30fb\u6587\u732e<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1.https:\/\/www.jmedj.co.jp\/blogs\/product\/product_26216<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30c3\u30f4\u30a3\uff1a\u7247\u982d\u75db\u4e88\u9632\u85ac\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u306e\u627f\u8a8d\u3092\u7533\u8acb\uff3b\u65b0\u85ac\u958b\u767a\u30fb\u8ca9\u58f2 FRONTLINE\uff3d \u2013 \u65e5\u672c\u533b\u4e8b\u65b0\u5831\u793e\u3000<\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">2\uff09https:\/\/medical.nikkeibp.co.jp\/leaf\/all\/series\/drug\/update\/202604\/592703.html<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7247\u982d\u75db\u4e88\u9632\u306b2\u5264\u76ee\u306e\u7d4c\u53e3CGRP\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3001\u672b\u671f\u814e\u4e0d\u5168\u60a3\u8005\u306b\u3082\u6295\u4e0e\u53ef\u80fd\uff1a\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\uff09Sakai\u3000F,\u3000et\u3000al.\u3000Prevalence\u3000of migraine in Japan: a nationwide survey. Cephalalgia.1997;17(1):15-22.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4\uff09Takeshima T, et al. Population-based door-to-door survey of migraine in Japan: the Daisen study. Headache. 2004;44(1):8-19.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7247\u982d\u75db\u306e\u75c5\u614b\u751f\u7406\u306b\u304a\u3051\u308bCGRP\u306e\u5f79\u5272\u3068\u30a2\u30af\u30a4\u30d7\u30bf<\/strong><strong>\ud83c\udd2c<\/strong><strong>\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"418\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-3-800x418.png\" alt=\"\" class=\"wp-image-1392\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-3-800x418.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-3-400x209.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-3.png 850w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u56f3\u3000\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306e\u4f5c\u7528\u6a5f\u5e8f\u3000\u2460\u21d2\u2461\u21d2\u2462\u21d2\u7247\u982d\u75db\u767a\u4f5c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Clin Transl Sci. 2024 Jan;17(1):e13707. doi: 10.1111\/cts.13707.Atogepant: Mechanism of action, clinical and translational science\u3000Ramesh Boinpally , Mohamad Shebley , Joel M Trugman \u3088\u308a\u629c\u7c8b\u4e00\u90e8\u5909\u66f4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7247\u982d\u75db\u767a\u4f5c\u6642\u306b\u306fCGRP\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u307e\u3059\u304c\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306f\u3001CGRP\u53d7\u5bb9\u4f53\u306b\u304a\u3044\u3066\u3001\u672b\u68a2\u795e\u7d4c\u3088\u308a\u653e\u51fa\u3055\u308c\u305fCGRP\u306e\u50cd\u304d\u3092\u62ee\u6297\u963b\u5bb3\u3057\u3001\u7247\u982d\u75db\u767a\u4f5c\u3092\u6291\u5236\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732eClin Transl Sci. 2024 Jan;17(1):e13707. doi: 10.1111\/cts.13707.Atogepant: Mechanism of action, clinical and translational science\u3000Ramesh Boinpally , Mohamad Shebley , Joel M Trugman<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ed6\u306eCGRP\u95a2\u9023\u88fd\u5264\u306e\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u4e0b\u306e\u8868\u306b\u307e\u3068\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>CGRP<\/strong><strong>\u95a2\u9023\u88fd\u5264\u306e\u4f5c\u7528\u306b\u3064\u3044\u3066<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"558\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-2-800x558.png\" alt=\"\" class=\"wp-image-1391\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-2-800x558.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-2-400x279.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-2.png 854w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30e0\u30ac\u30eb\u30c7\u30a3\ud83c\udd2c\u3001\u30a2\u30a4\u30e2\u30d3\u30fc\u30b0\ud83c\udd2c\u3001\u30a2\u30b8\u30e7\u30d3\ud83c\udd2c\u306f\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308a\u9ad8\u5206\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u30b2\u30cf\u30f3\u30c8\u3068\u3044\u308f\u308c\u308b\u3001\u30ca\u30eb\u30c6\u30fc\u30af\ud83c\udd2c\u3068\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306f\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30c8\u30ea\u30d7\u30bf\u30f3\u88fd\u5264\u306f\u3001\u30ec\u30a4\u30dc\u30fc\ud83c\udd2c\u3068\u540c\u69d8\u306b\u3001CGRP\u653e\u51fa\u3092\u6291\u5236\u3057\u307e\u3059\u304c\u3001\u52a0\u3048\u3066\u8133\u8840\u7ba1\u53ce\u7e2e\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u3010\u30ea\u30b6\u30c8\u30ea\u30d7\u30bf\u30f3\uff08\u30de\u30af\u30b5\u30eb\u30c8\ud83c\udd2c\uff09\u3001\u30a8\u30ec\u30c8\u30ea\u30d7\u30bf\u30f3\uff08\u30ec\u30eb\u30d1\u30c3\u30af\u30b9\ud83c\udd2c\uff09\u3001\u30be\u30eb\u30df\u30c8\u30ea\u30d7\u30bf\u30f3\uff08\u30be\u30fc\u30df\u30c3\u30b0\ud83c\udd2c\uff09\u3001\u30b9\u30de\u30c8\u30ea\u30d7\u30bf\u30f3\uff08\u30a4\u30df\u30b0\u30e9\u30f3\ud83c\udd2c\uff09\u3001\u30ca\u30e9\u30c8\u30ea\u30d7\u30bf\u30f3\uff08\u30a2\u30de\u30fc\u30b8\ud83c\udd2c\uff09\u3011<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e\u3000Pain\u3000Clinic\u3000Vol\u300045\u3000No\uff0e6\uff082024\uff0e6\uff09625\uff0d634\u3000CGRP\u95a2\u9023\u7247\u982d\u75db\u65b0\u6cbb\u7642\u85ac\u3068\u30b8\u30bf\u30f3\u7cfb \u3000\u982d\u75db\u6cbb\u7642\u85ac\u306e\u610f\u7fa9\u3068\u5b9f\u8df5 \u3000\u524d\u7530\u3000\u502b<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u85ac\u4fa1<\/strong>\u30fb\u30fb\u30fb\u4ed6\u306eCGRP\u88fd\u5264\u3068\u307b\u307c\u540c\u69d8\u306e\u91d1\u984d\u304c\u304b\u304b\u308a\u307e\u3059\u3002<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u85ac\u4fa1\uff08\uff12\uff10\uff12\uff16\u5e74\uff18\u6708\uff11\uff12\u65e5\u73fe\u5728\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">10mg\uff11\u9320339.90\u5186<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">30mg\uff11\u9320831.30\u5186\u3000\u3000\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">60mg\uff11\u93201461.60\u5186\u30fb\u30fb\u30fb30\u65e530\u9320\u306743848\u5186<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083\u5272\u8ca0\u62c5\u3067\u8a08\u7b97\u3059\u308b\u306813155\u5186\/30\u65e5\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ed6\u306eCGRP\u88fd\u5264\u306e\u85ac\u4fa1\uff1a\uff08\uff12\uff10\uff12\uff16\u5e74\uff18\u6708\uff11\uff12\u65e5\u73fe\u5728\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30e0\u30ac\u30eb\u30c6\u30a3\ud83c\udd2c\uff08\u30aa\u30fc\u30c8\u30a4\u30f3\u30b8\u30a7\u30af\u30bf\u30fc42400\u5186\uff0f\u30ad\u30c3\u30c8\u30fb42284\u5186\/\u7b52\uff09\u3000\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30b8\u30e7\u30d3\ud83c\udd2c\uff08\u30aa\u30fc\u30c8\u30a4\u30f3\u30b8\u30a7\u30af\u30bf\u30fc38856\u5186\uff0f\u30ad\u30c3\u30c8\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30a4\u30e2\u30d3\u30fc\u30af\ud83c\udd2c\uff08\u76ae\u4e0b\u6ce8\uff17\uff10\uff4d\uff47\u30da\u30f338842\u5186\uff0f\u30ad\u30c3\u30c8\uff09\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\uff08OD\u9320\uff17\uff15\uff4d\uff472923.2\u5186\uff0f\u9320\uff09\u30fb\u30fb\u30fb30\u65e515\u9320\u306743848\u5186<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083\u5272\u8ca0\u62c5\u3067\u8a08\u7b97\u3059\u308b\u306813155\u5186\/30\u65e5\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u8cc7\u6599\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5404\u85ac\u5264\u306e\u533b\u7642\u7528\u533b\u85ac\u54c1\u306e\u6dfb\u4ed8\u6587\u66f8\u60c5\u5831\uff08\uff12\uff10\uff12\uff16\u5e74\uff18\u6708\uff11\uff12\u65e5\u73fe\u5728\uff09\u3092\u53c2\u8003\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u526f\u4f5c\u7528\u3068\u3057\u3066<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6dfb\u4ed8\u6587\u66f8\u4e0a\u306b\u904e\u654f\u75c7\u53cd\u5fdc\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u5341\u5206\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u305d\u306e\u4ed6\u306e\u526f\u4f5c\u7528\u3068\u3057\u3066\u4e3b\u306a\u3082\u306e\u306b\u3001\u60aa\u5fc3\u3001\u4fbf\u79d8\u3001\u98df\u6b32\u6e1b\u9000\u3001\u50be\u7720\u3001\u4f53\u91cd\u6e1b\u5c11\u3001ALT\/AST\u5897\u52a0\uff08\u54041\uff05\u4ee5\u4e0a\uff09\u306e\u8a18\u8f09\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u85ac\u5264\u4f7f\u7528\u306b\u969b\u3057\u3066\u3001\u4e0b\u8a18\u306e\u4e8b\u9805\u306b\u3064\u3044\u3066\u3082\u7559\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u814e\u6a5f\u80fd\u4f4e\u4e0b\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u5ea6\u306e\u814e\u6a5f\u80fd\u969c\u5bb3\u60a3\u8005\u304a\u3088\u3073\u672b\u671f\u814e\u4e0d\u5168\u60a3\u8005\uff08\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u30af\u30ea\u30a2\u30e9\u30f3\u30b930mL\/\u5206\u672a\u6e80\uff09\u306b\u6295\u4e0e\u3059\u308b\u5834\u5408\u30011\u65e51\u56de\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c10mg\u3092\u6295\u4e0e\u3059\u308b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u91cd\u75c7\u814e\u6a5f\u80fd\u60a3\u8005\u306b\u5bfe\u3059\u308b\u8a66\u9a13\u306f\u5b9f\u65bd\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u4f7f\u7528\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>OATP<\/strong><strong>\u963b\u5bb3\u85ac\u3068\u4f75\u7528\u3059\u308b\u5834\u5408<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">1\u65e51\u56de30mg\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">OATP\u963b\u5bb3\u85ac\u306f\u3001OATP\u3068\u3044\u3046\u53d6\u308a\u8fbc\u307f\u8f38\u9001\u4f53\u306e\u50cd\u304d\u3092\u5f31\u3081\u3001\u8840\u6db2\u4e2d\u306e\u85ac\u304c\u809d\u7d30\u80de\u3078\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3053\u3068\u3092\u963b\u5bb3\u3057\u85ac\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u3002\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3,&nbsp;\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3,&nbsp;\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3,&nbsp;\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3,&nbsp;\u30ed\u30d4\u30ca\u30d3\u30eb\u3068\u30ea\u30c8\u30ca\u30d3\u30eb,&nbsp;\u30b7\u30e1\u30d7\u30ec\u30d3\u30eb\u306a\u3069\u304c\u3053\u308c\u306b\u3042\u305f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>CYP3A<\/strong><strong>\u963b\u5bb3\u5264\u3068\u306e\u4f75\u7528\u3059\u308b\u5834\u5408<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001CYP3A\u306f\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3092\u4ee3\u8b1d\u3059\u308b\u9175\u7d20\u3067\u3059\u304c\u3001CYP3A\u963b\u5bb3\u5264\u306f\u3001\u8840\u4e2d\u6fc3\u5ea6\u306e\u4e0a\u6607\u3092\u62db\u304d\u307e\u3059\u3002CYP3A\u963b\u5bb3\u5264\u3068\u306e\u4f75\u7528\u3059\u308b\u5834\u5408\u30011\u65e51\u56de\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c10mg\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002OATP\u963b\u5bb3\u5264\u3067\u3042\u308a\u5f37\u529b\u306aCYP3A\u963b\u5bb3\u5264\u3067\u3082\u3042\u308b\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u3092\u53cd\u5fa9\u6295\u4e0e\u3057\u305f\u3068\u304d\u306f\u3001\u8840\u4e2d\u6fc3\u5ea6\u306f\u304b\u306a\u308a\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CYP3A\u963b\u5bb3\u5264\u3068\u3057\u3066\u306f\u3001\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb\u3084\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u809d\u6a5f\u80fd\u4f4e\u4e0b\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Child-Pugh C\uff08\u91cd\u75c7\u306e\u809d\u6a5f\u80fd\u4f4e\u4e0b\u72b6\u614b\uff09\u306e\u60a3\u8005\u3055\u3093\u306e\u6295\u4e0e\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u598a\u5a66\u3055\u3093\u306e\u5834\u5408<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7642\u4e0a\u306e\u6709\u76ca\u6027\u304c\u5371\u967a\u6027\u3092\u4e0a\u56de\u308b\u3068\u5224\u65ad\u3055\u308c\u308b\u5834\u5408\u306b\u306e\u307f\u6295\u4e0e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30e9\u30c3\u30c8\u306b\u304a\u3044\u3066\u306f\u300110.9\u500d\u4ee5\u4e0a\u306e\u7528\u91cf\u6295\u4e0e\u3067\u6bcd\u4f53\u6bd2\u6027\u306b\u4f34\u3046\u80ce\u5150\u4f53\u91cd\u306e\u6e1b\u5c11\u53ca\u3073\u9aa8\u683c\u7570\u5e38\u306e\u767a\u73fe\u983b\u5ea6\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6388\u4e73\u5a66\u3055\u3093\u306e\u5834\u5408<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bcd\u4e73\u3078\u306e\u79fb\u884c\u304c\u8a8d\u3081\u3089\u308c\u308b\u305f\u3081\u3001\u6388\u4e73\u306e\u7d99\u7d9a\u53c8\u306f\u4e2d\u6b62\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u5c0f\u5150<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c0f\u5150\u306b\u305f\u3044\u3059\u308b\u8a66\u9a13\u306f\u5b9f\u65bd\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u5c0f\u5150\u3078\u306e\u6295\u4e0e\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4fdd\u5b58\u65b9\u6cd5<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u5ba4\u6e29\u4fdd\u5b58\u3067 \u6709\u52b9\u671f\u9593\u306f\u300136\u30f5\u6708\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u8cc7\u6599\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbhttps:\/\/www.kegg.jp\/medicus-bin\/japic_med?japic_code=00071998\u533b\u7642\u7528\u533b\u85ac\u54c1 : \u30a2\u30af\u30a4\u30d7\u30bf (\u30a2\u30af\u30a4\u30d7\u30bf\u932060mg \u4ed6)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb2026\u5e742\u6708\u4f5c\u6210\uff08\u7b2c1\u7248\uff09\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u6dfb\u4ed8\u6587\u66f8<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a2\u30af\u30a4\u30d7\u30bf<\/strong><strong>\ud83c\udd2c<\/strong><strong>\u3068<\/strong><strong>\u30ca\u30eb\u30c6\u30a3\u30fc\u30af<\/strong><strong>\ud83c\udd2c<\/strong><strong>\u306e\u9055\u3044\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306f\u3001\u73fe\u6642\u70b9\u3067\u306f\u3001\u7247\u982d\u75db\u4e88\u9632\u85ac\u3068\u3057\u3066\u306e\u307f\u4f7f\u7528\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7247\u982d\u75db\u306e\u6025\u6027\u767a\u4f5c\u6642\u306eCGRP\u95a2\u9023\u88fd\u5264\u306f\u3001\u73fe\u6642\u70b9\u3067\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c \u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u4e88\u9632\u85ac\u3068\u3057\u3066\u3082\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306e\u65b9\u304c\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3088\u308a\u6c4e\u7528\u6027\u306e\u9762\u304b\u3089\u826f\u3044\u5370\u8c61\u304c\u3042\u308a\u307e\u3059\u3002\u4f46\u3057\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306f\u3001\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u3067\u306f\u6295\u4e0e\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3068\u3055\u308c\u308b\u672b\u671f\u814e\u4e0d\u5168\u60a3\u8005\u306b\u5bfe\u3057\u3066\u300110\u338e\u306b\u6e1b\u91cf\u3057\u3066\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7247\u982d\u75db\u4e88\u9632\u85ac\u3068\u3057\u3066\u306e\u52b9\u679c\u306f\u3001\u30a2\u30af\u30a4\u30d7\u30bf<\/strong><strong>\ud83c\udd2c<\/strong><strong>\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af<\/strong><strong>\ud83c\udd2c<\/strong><strong>\u306e\u3069\u3061\u3089\u304c\u6709\u52b9\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306b\u3064\u3044\u3066\u306f\u3001\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u3068\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306f\u3068\u3082\u306b\u65b0\u3057\u3044CGRP\u95a2\u9023\u88fd\u5264\u3067\u3001\u73fe\u6642\u70b9\u3067\u76f4\u63a5\u306b\u6bd4\u8f03\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306b\u76f4\u63a5\u306e\u6bd4\u8f03\u8a66\u9a13\u304c\u5b58\u5728\u3057\u306a\u3044\u72b6\u6cc1\u3067\u306f\u3001\u5404\u8a66\u9a13\u306e\u7d50\u679c\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3066\u3001 \u9593\u63a5\u7684\u306b\u85ac\u5264\u9593\u306e\u6cbb\u7642\u52b9\u679c\u3092\u63a8\u5b9a\u3059\u308b\u65b9\u6cd5\u304c\u3068\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8981\u3059\u308b\u306b\u3001\u300cA\uff56s B\u300d\u306e\u76f4\u63a5\u6bd4\u8f03\u304c\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u306b\u3001\u300cA vs \u30d7\u30e9\u30bb\u30dc\u300d\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u3068\u300cB vs \u30d7\u30e9\u30bb\u30dc\u300d\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u3092\u7d71\u5408\u3057\u3066\u3001\u9593\u63a5\u7684\u306b\u300cA vs B\u300d\u3092\u63a8\u5b9a\u3059\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\u610f\u70b9\u3068\u3057\u3066\u3001\u3053\u306e\u89e3\u6790\u306b\u4f7f\u7528\u3055\u308c\u308b\u30d7\u30e9\u30bb\u30dc\u7fa4\u306f\u3001A\u3068B\u3068\u3067\u306f\u7570\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u8a55\u4fa1\u57fa\u6e96\u304c\u7570\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u85ac\u5264\u306e\u52b9\u679c\u5224\u5b9a\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u30d0\u30a4\u30a2\u30b9\u3092\u52a0\u5473\u3057\u3066\u8003\u5bdf\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306b\u3064\u3044\u3066\u306a\u3055\u308c\u305f\u8ad6\u6587\u2460\u2461\u2462\u2463\u306b\u3064\u3044\u3066\u7c21\u6f54\u306b\u7d50\u679c\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u65e5\u672c\u4eba\u306b\u304a\u3044\u3066\u884c\u308f\u308c\u305f\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306e\u982d\u75db\u65e5\u6570\u6e1b\u5c11\u306b\u3064\u3044\u3066\u306e\u6bd4\u8f03\u89e3\u6790\u306e\u7d50\u679c\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Expert Rev Neurother. 2026 Jan;26(1):91-100. doi: 10.1080\/14737175.2025.2599853. Epub 2025 Dec 21.Comparative effectiveness of atogepant and rimegepant for migraine prevention in Japanese patients: an anchored matching-adjusted indirect comparison<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tsubasa Takizawa , Gina Ahmadyar, Emma Tyas, Molly Duan , Ifeanyi Ubamadu , Toru Yamazaki , Haris Jameel , Judy Chen , Keisuke Suzuki , Noboru Imai , Yoichiro Hashimoto , Naoko Sanno , Hisaka Igarashi , Pranav Gandhi , Mamoru Shibata<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u3064\u306e\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c(\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8)\u8a66\u9a13\u3068\u3057\u3066RELEASE\u8a66\u9a13\u3068 PROGRESS\u8a66\u9a13\u3001\u305d\u3057\u3066\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\uff08\u30ea\u30e1\u30b2\u30cf\u30f3\u30c8\uff09\u8a66\u9a13\u3068\u3057\u3066BHV3000-309\u8a66\u9a13\u304c\u89e3\u6790\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"368\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-800x368.png\" alt=\"\" class=\"wp-image-1389\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-800x368.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-400x184.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image.png 850w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u306e\u30b0\u30e9\u30d5\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u85ac\u5264\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08\u507d\u85ac\u7fa4\uff09\u3068\u6bd4\u3079\u6708\u9593\u5e73\u5747\u982d\u75db\u56de\u6570\u304c\u3069\u308c\u3060\u3051\u4f4e\u4e0b\u3057\u305f\u304b\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u30b0\u30e9\u30d5\uff08a\uff09\u3088\u308a\u300112\u9031\u9593\u306e\u671f\u9593\u306b\u304a\u3044\u3066\u3001\u5e73\u5747\u3057\u3066\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u304c\u30012.83\u65e5\u982d\u75db\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306f\u30011.50\u65e5\u982d\u75db\u304c\u6e1b\u5c11\u3057\u305f\u3053\u3068\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\uff08\uff42\uff09\u306b\u3088\u308b\u3068\u4e88\u9632\u85ac\u6295\u4e0e\u306e\u521d\u671f\uff08\u6700\u521d\u306e\uff11\u30ab\u6708\uff09\u3088\u308a\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c60\u338e\u306e\u307b\u3046\u304c\u3001\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c75\u338e\u3088\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u7d71\u8a08\u7684\u306b\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u982d\u75db\u56de\u6570\u304c\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001\u5f8c\u534a\u306e\u671f\u9593\u306b\u304a\u3044\u3066\u3082\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306e\u65b9\u304c\u3001\u982d\u75db\u306e\u767a\u751f\u983b\u5ea6\u304c\u5c11\u306a\u304b\u3063\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30b0\u30e9\u30d5\u306f\u8a18\u8f09\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u6708\u9593\u3067\u306e\u5e73\u5747\u6025\u6027\u85ac\u4f7f\u7528\u65e5\u6570\u3082\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306e\u65b9\u304c\u5c11\u306a\u304b\u3063\u305f\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u88dc\u8db3\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u8a55\u4fa1\u65b9\u6cd5\uff1a\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306e\u8a66\u9a13\u3067\u5b9f\u65bd\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08\u507d\u85ac\u4f7f\u7528\uff09\u306b\u3088\u3063\u3066\u3082\u982d\u75db\u65e5\u6570\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u8a55\u4fa1\u65b9\u6cd5\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u982d\u75db\u65e5\u6570\u3092\u57fa\u6e96\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\uff09\u306b\u3057\u3066\u3001\uff12\u5264\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u3066\u3069\u308c\u3050\u3089\u3044\u65e5\u6570\u304c\u6e1b\u5c11\u3057\u305f\u304b\u3067\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7d71\u8a08\u7684\u6709\u610f\uff1a\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\uff12\u85ac\u5264\u9593\u306b\u304a\u3044\u3066\u3001\u982d\u75db\u767a\u751f\u65e5\u6570\u6e1b\u5c11\u306e\u7a0b\u5ea6\u306b\u7d71\u8a08\u7684\u306b\u6709\u610f\u5dee\u304c\u3042\u308b\u304b\u3092\u307f\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff19\uff15%\u4fe1\u983c\u533a\u9593\uff08\uff19\uff15%\u306e\u78ba\u7387\u3067\u305d\u306e\u533a\u9593\u306e\u4e2d\u306b\u5e73\u5747\u5024\u304c\u542b\u307e\u308c\u308b\u3053\u3068\u3092\u8868\u3059\uff09\u306b\u304a\u3044\u3066\uff10\u3092\u307e\u305f\u3044\u3067\u3044\u306a\u3044\u3053\u3068\u3001\u2605\u5370\u306f\u6709\u610f\u5dee\u3042\u308a\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u306e\u30b0\u30e9\u30d5\u3067\u306f\u3001\uff08\uff0d2.48\u304b\u3089\uff0d0.18\uff09<sup>\u2605<\/sup>\u3001\uff08\uff0d2.74\u304b\u3089\uff0d0.31\uff09<sup>\u2605<\/sup>\u3001\uff08\uff0d2.97\u304b\u3089\u20150.16\uff09<sup>\u2605<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3059\u3079\u3066\uff10\u3092\u307e\u305f\u3044\u3067\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6d77\u5916\u306b\u304a\u3044\u3066\u884c\u308f\u308c\u305f\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306e\u982d\u75db\u65e5\u6570\u6e1b\u5c11\u306b\u3064\u3044\u3066\u306e\u6bd4\u8f03\u89e3\u6790\u306e\u7d50\u679c\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Cephalalgi. 2024 Feb;44(2):3331024241235156. doi: 10.1177\/03331024241235156.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Comparative efficacy, quality of life, safety, and tolerability of atogepant and rimegepant in migraine prevention: A matching-adjusted indirect comparison analysis<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cristina Tassorelli , Kateryna Onishchenko , Rashmi B Halker Singh , Molly Duan , Laure Dupont-Benjamin , Matthew Hemstock , Corey Voller , Peter McAllister , Stephanie J Nahas , Pranav Gandhi , Jessica Ailani \u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u3064\u306e\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u8a66\u9a13\u3067\u3042\u308bADVANCE\u3068PROGRESS\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u8a66\u9a13\u3067\u3042\u308bBHV3000-305\u306e\u53c2\u52a0\u8005\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u7247\u982d\u75db\u4e88\u9632\u85ac\u3068\u3057\u3066\u306e\u6cbb\u7642\u52b9\u679c\u306e\u6bd4\u8f03\u3092\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"480\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-1-800x480.png\" alt=\"\" class=\"wp-image-1390\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-1-800x480.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-1-400x240.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-1.png 851w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08a\uff09\u8a66\u9a13\u671f\u9593\uff13\u304b\u6708\u306e\u9593\u3001\uff08b\uff09\uff19\uff0d\uff11\uff12\u9031\u306e\u8a66\u9a13\u671f\u9593\u306e\u5f8c\u534a\u306b\u304a\u3044\u3066\u5171\u306b\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306e\u7fa4\u3067\u6708\u5e73\u5747\u306e\u982d\u75db\u767a\u751f\u65e5\u6570\u304c\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6d77\u5916\u306b\u304a\u3044\u3066\u884c\u308f\u308c\u305f\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u5185\u670d\u306b\u3088\u308b\u306e\u982d\u75db\u983b\u5ea6\u6e1b\u5c11\u306e\u5272\u5408\u3092\u6bd4\u8f03\u89e3\u6790\u3057\u305f\u7d50\u679c\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Headache. 2024 Nov-Dec;64(10):1253-1263. doi: 10.1111\/head.14824. Epub 2024 Sep 9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cost per treatment responder analysis of atogepant compared to rimegepant for the preventive treatment of episodic migraine<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jessica Ailani , Pranav Gandhi , Anjana Lalla , Rashmi Halker Singh , Peter McAllister , Jonathan H Smith , Brett Dabruzzo , Natty Chalermpalanupap , Kari Kelton , Stephanie J Nahas<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7c73\u56fd\u3067\u53cd\u5fa9\u6027\u7247\u982d\u75db\u60a3\u8005\u306b\u5bfe\u3057\u3066\u4e88\u9632\u85ac\u3068\u3057\u3066\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u3068\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306e\u6cbb\u7642\u306b\u3088\u308b\u3001\u982d\u75db\u983b\u5ea6\u304c\u6e1b\u5c11\u3057\u305f\u5272\u5408\u306b\u3064\u3044\u3066\u306e\u5206\u6790\u3092\u304a\u3053\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306eADVANCE\u8a66\u9a13\u304a\u3088\u3073\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306eBHV3000-305\u8a66\u9a13\u306e\u767b\u9332\u8a66\u9a13\u306e\u516c\u958b\u30c7\u30fc\u30bf\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<strong><\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d50\u679c<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"473\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-5-800x473.png\" alt=\"\" class=\"wp-image-1394\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-5-800x473.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-5-400x237.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/08\/image-5.png 847w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u2267\uff15\uff10\uff05\u3000Responder\uff1a\u5185\u670d\u306b\u3088\u3063\u3066\u4e2d\u7b49\u5ea6\u304b\u3089\u91cd\u5ea6\u306e\u7247\u982d\u75db\u306e\u767a\u751f\u65e5\u6570\u304c\uff15\uff10%\u4ee5\u4e0a\u6e1b\u5c11\u3057\u305f\u3082\u306e\u3092\u2267\uff15\uff10\uff05\u30ea\u30b9\u30dd\u30f3\u30c0\u30fc\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff15\uff10\uff05\u4ee5\u4e0a\u982d\u75db\u983b\u5ea6\u304c\u6e1b\u5c11\u3057\u305f\u5272\u5408\u306f\u3001\u30ca\u30eb\u30c6\u30a3\u30fc\u30af\ud83c\udd2c\u306e51.8\uff05\u306b\u5bfe\u3057\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306e\u65b9\u304c64.9\uff05\u3068\u9ad8\u3044\u7d50\u679c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u306e\u6bd4\u8f03\u3067\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306f\u3001\u4fe1\u983c\u533a\u9593\u306b\u91cd\u306a\u308a\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044\u3053\u3068\u304b\u3089\u5185\u670d\u306b\u3088\u3063\u3066\u6709\u610f\u306b\u982d\u75db\u983b\u5ea6\u3092\u6e1b\u5c11\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u3053\u306e\u6587\u732e\u3067\u306f\u3001\u53cd\u5fa9\u6027\u7247\u982d\u75db\u306b\u5bfe\u3057\u3066\u3001\u30a2\u30af\u30a4\u30d7\u30bf\ud83c\udd2c\u306e\u8cbb\u7528\u5bfe\u52b9\u679c\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\u610f\u70b9\uff1a\u6587\u732e\u2461\u2462\u306e\u7814\u7a76\u306b\u4f7f\u308f\u308c\u305f\u60a3\u8005\u7fa4\u306f\u3001\u4e00\u90e8\u91cd\u306a\u3063\u3066\u3044\u307e\u3059\uff08ADVANCE\u8a66\u9a13\u3068BHV3000-305\u8a66\u9a13\uff09\u3002\u4f3c\u901a\u3063\u305f\u7d50\u679c\u306b\u306a\u3063\u305f\u53ef\u80fd\u6027\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6162\u6027\u7247\u982d\u75db\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3059\u308b\u4e88\u9632\u85ac\u306e\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u96c6\u3081\u3066\u89e3\u6790\u3057\u305f\u8ad6\u6587\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ann Intern Med. 2026 Jun;179(6):823-834. doi: 10.7326\/ANNALS-25-02221.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;Epub 2026 May 5. 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