{"id":1239,"date":"2026-06-07T09:00:10","date_gmt":"2026-06-07T00:00:10","guid":{"rendered":"https:\/\/ito-pain.com\/blog\/?p=1239"},"modified":"2026-06-07T14:52:41","modified_gmt":"2026-06-07T05:52:41","slug":"post-1239","status":"publish","type":"post","link":"https:\/\/ito-pain.com\/blog\/post-1239\/","title":{"rendered":"\u65b0\u898f\u306e\u7761\u7720\u85ac \u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30dc\u30eb\u30ba\u30a3\u00ae\uff09\u306e\u6301\u3061\u8d8a\u3057\u52b9\u679c\uff08\u7fcc\u65e5\u306e\u7720\u6c17\uff09\u306f\uff1f"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u3044\u3068\u3046\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af\u9662\u9577\u306e\u4f0a\u85e4\u3067\u3059\u3002\u30aa\u30ec\u30ad\u30b7\u30f3\u306f\u8996\u5e8a\u4e0b\u90e8\u306b\u5c40\u5728\u3059\u308b\u795e\u7d4c\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001\u899a\u9192\u7dad\u6301\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff08DORA\uff09\u306f\u3001\u30aa\u30ec\u30ad\u30b7\u30f31\uff08OX1\uff09\u53d7\u5bb9\u4f53\u304a\u3088\u3073\u30aa\u30ec\u30ad\u30b7\u30f32\uff08OX2\uff09\u53d7\u5bb9\u4f53\u306b\u5bfe\u3057\u3066\u3001\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u306e\u30aa\u30ec\u30ad\u30b7\u30f3\u3068\u62ee\u6297\u4f5c\u7528\u306b\u3088\u3063\u3066\u899a\u9192\u7cfb\u3092\u6291\u5236\u3057\u3001\u751f\u7406\u7684\u306a\u7761\u7720\u3092\u8a98\u5c0e\u3059\u308b\u85ac\u5264\u3067\u3059\u3002DORA\u306f\u3001\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u3001Z\u7cfb\u7761\u7720\u85ac\u306b\u6bd4\u3079\u3001\u5b89\u5168\u6027\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2025\u5e7411\u670827\u65e5\u3088\u308a\u3001\u7b2c4\u756a\u76ee\u306e\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff08DORA\uff09\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30dc\u30eb\u30ba\u30a3\u00ae\uff09\u304c\u3001\u4f7f\u7528\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u7761\u7720\u85ac\u306e\u526f\u4f5c\u7528\u3068\u3057\u3066\u3001\u7fcc\u65e5\u306e\u6301\u3061\u8d8a\u3057\u4f5c\u7528\uff08\u7720\u6c17\uff09\u304c\u3042\u308a\u307e\u3059\u304c\u3001DORA\u306e\u4e2d\u3067\u6700\u3082\u77ed\u3044\u534a\u6e1b\u671f\u3092\u6301\u3061\u3001\u7fcc\u65e5\u306e\u6301\u3061\u8d8a\u3057\u30ea\u30b9\u30af\u304c\u3088\u308a\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u65e5\u85ac\u7406\u8a8c\uff08Folia Pharmacol. Jpn.\uff09161\uff0c192\uff5e197\uff082026\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DOI:https:\/\/doi.org\/10.1254\/fpj.25096 \u65b0\u898f\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30dc\u30eb\u30ba\u30a3\u00ae\u93202.5mg\uff0c5mg\uff0c10mg\uff09\u306e\u85ac\u7406\u5b66\u7684\u7279\u5fb4\u3068\u81e8\u5e8a\u8a66\u9a13\u6210\u7e3e \u6a2a\u7530 \u9065\uff0c\u5730\u91ce \u4e4b\u6d69\uff0c\u67f4\u5c71 \u52a0\u4e16\u5b50\uff0c\u8336\u6728 \u8302\u4e4b\uff0c\u4eca\u5bfa \u7950\u7f8e\u5b50<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fbInt J Neuropsychopharmacol. 2025 Dec 1;28(12):pyaf077. doi: 10.1093\/ijnp\/pyaf077. Current and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant Yukihiro Chino, Hiroyuki Sugiyama , Shigeyuki Chaki , Yuri Sato<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\u5148\u884c\u306e3\u3064\u306e\u4e8c\u91cd\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8(DORA)\u3067\u3042\u308b\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\uff09\u3001\u30ec\u30f3\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30c7\u30a8\u30d3\u30b4\u00ae\uff09\u3001\u30c0\u30ea\u30c9\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae\uff09\u306f\u3001\u7fcc\u65e5\u306e\u6301\u3061\u8d8a\u3057\u52b9\u679c\u306b\u95a2\u3057\u3066\u3001\u6dfb\u4ed8\u6587\u66f8\u306b\u306f\u300c\u672c\u5264\u306e\u5f71\u97ff\u304c\u670d\u7528\u306e\u7fcc\u671d\u4ee5\u5f8c\u306b\u53ca\u3073\u3001\u7720\u6c17\u3001\u6ce8\u610f\u529b\u30fb\u96c6\u4e2d\u529b\u30fb\u53cd\u5c04\u904b\u52d5\u80fd\u529b\u7b49\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3001<strong>\u81ea\u52d5\u8eca\u306e\u904b\u8ee2\u306a\u3069\u5371\u967a\u3092\u4f34\u3046\u6a5f\u68b0\u306e\u64cd\u4f5c\u306b\u5f93\u4e8b\u3055\u305b\u306a\u3044\u3088\u3046\u6ce8\u610f\u3059\u308b\u3053\u3068\u3002<\/strong>\u300d\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u30dc\u30eb\u30ba\u30a3\u00ae\u306e\u6dfb\u4ed8\u6587\u66f8\u306b\u306f\u3001\u300c\u4e0d\u7720\u75c7\u3042\u308b\u3044\u306f\u672c\u5264\u306e\u5f71\u97ff\u306b\u3088\u308a\u3001\u7720\u6c17\u3001\u6ce8\u610f\u529b\u30fb\u96c6\u4e2d\u529b\u30fb\u53cd\u5c04\u904b\u52d5\u80fd\u529b\u7b49\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u60a3\u8005\u306e\u72b6\u614b\u3092\u5341\u5206\u306b\u628a\u63e1\u3057\u305f\u4e0a\u3067\u3001<strong>\u81ea\u52d5\u8eca\u306e\u904b\u8ee2\u7b49\u306e\u5371\u967a\u3092\u4f34\u3046\u6a5f\u68b0\u3092\u64cd\u4f5c\u3059\u308b\u3053\u3068\u306e\u9069\u5426\u3092\u614e\u91cd\u306b\u5224\u65ad\u3057\u3001\u5371\u967a\u3092\u4f34\u3046\u4f5c\u696d\u7b49\u3092\u884c\u3046\u5834\u5408\u306b\u306f\u5341\u5206\u306a\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u9069\u5207\u306b\u60a3\u8005\u306b\u6307\u5c0e\u3059\u308b\u3053\u3068\u3002<\/strong>\u300d\u3068\u306e\u8a18\u8f09\u3067\u3042\u308a\u3001\u5148\u884c of 3\u3064\u306e\u7761\u7720\u85ac\u3068\u306f\u8a18\u8f09\u306e\u3055\u308c\u65b9\u304c\u7570\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p 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has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e1\uff09Psychiatry and Clinical Neurosciences 79: 757\u2013764, 2025 Driving performance in the morning after bedtime vornorexant administration: A randomized clinical trial using a driving simulator Yusuke Miyazaki, MS , Kunihiro Iwamoto, MD, PhD, Daiji Kambe, PhD, Yumiko Imadera, MS, Isao Matsushita, MS and Norio Ozaki, MD, PhD<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c810mg\u304a\u3088\u307320mg\u306e\u5358\u56de\u304a\u3088\u3073\u53cd\u5fa9\u6295\u4e0e\u306f\u3001\u5065\u5eb7\u306a\u65e5\u672c\u4eba\u53c2\u52a0\u8005\u306b\u304a\u3051\u308b\u904b\u8ee2\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u81e8\u5e8a\u7684\u306b\u6709\u610f\u306a\u969c\u5bb3\u3092\u8a98\u767a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305a\u306f\u3001\u30dc\u30eb\u30ba\u30a3\u00ae10mg\u307e\u3067\u3067\u306f\u6295\u4e0e\u7fcc\u65e5\u306e\u904b\u8ee2\u6280\u80fd\u7b49\u306e\u8a55\u4fa1\u3067\u81e8\u5e8a\u7684\u306b\u610f\u7fa9\u306e\u3042\u308b\u5f71\u97ff\u306f\u8a8d\u3081\u305a\u3001\u6301\u3061\u8d8a\u3057\u52b9\u679c\u3092\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3053\u3068\u304c\u81e8\u5e8a\u8a66\u9a13\u3088\u308a\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u7fcc\u65e5\u306e\u904b\u8ee2\u306b\u5bfe\u3057\u3066\u306e\u5b89\u5168\u6027\u306f\u9ad8\u305d\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b21\u306b\u3001DORA\u88fd\u5264\u306e\u6bd4\u8f03\u306b\u3088\u308b\u7fcc\u65e5\u306e\u6301\u3061\u8d8a\u3057\u52b9\u679c\uff08\u7720\u6c17\uff09\u306b\u5bfe\u3059\u308b\u6bd4\u8f03\u306b\u3064\u3044\u3066\u8a18\u8f09\u306e\u3042\u3063\u305f\u6587\u732e\u3092\u8abf\u3079\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e2\uff09Transl Psychiatry. 2025 Jun 24;15(1):211. doi: 10.1038\/s41398-025-03439-8. Comparative efficacy and safety of daridorexant, lemborexant, and suvorexant for insomnia: a systematic review and network meta-analysis Taro Kishi, Toshikazu Ikuta, Leslie Citrome, Kenji Sakuma, Masakazu Hatano, Shun Hamanaka, Yasufumi Nishii, Nakao Iwata<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001\u30d7\u30e9\u30bb\u30dc\uff08\u507d\u85ac\uff09\u3001\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae\u3001\u30c7\u30a8\u30d3\u30b4\u00ae\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u7720\u6c17\u306e\u5f37\u3055\u306b\u3064\u3044\u3066\u89e3\u6790\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7570\u8cea\u6027\u304c\u5927\u304d\u304b\u3063\u305f\u305f\u3081\u3001\u611f\u5ea6\u5206\u6790\u3067\u7570\u8cea\u6027\u304c\u5c11\u306a\u304f\u306a\u308b\u3088\u3046\u8abf\u6574\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3059\u3079\u3066\u306e\u85ac\u5264\u9593\u306e\u7720\u6c17\u306e\u5f37\u3055\u306b\u3064\u3044\u3066\u6bd4\u8f03\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6709\u610f\u5dee\u306f\u3001\u4fe1\u983c\u533a\u9593\u304c1.000\u3092\u307e\u305f\u3044\u3060\u5834\u5408\u3001\u7d71\u8a08\u7684\u306b\u306f\u6709\u610f\u5dee\u304c\u7121\u3044\u3068\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u304c\u3001\u4fe1\u983c\u533a\u9593\u306e\u632f\u308c\u5e45\u304c\u5927\u304d\u3044\u306e\u3067\u3001\u4fe1\u983c\u533a\u9593\uff08\u6709\u610f\u5dee\uff09\u3092\u7121\u8996\u3057\u3066\u307f\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d7\u30e9\u30bb\u30dc\uff08\u507d\u85ac\uff1a\u7761\u7720\u85ac\u306e\u4f5c\u7528\u306a\u3057\uff09\u306b\u5bfe\u3057\u3066\u306e\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae\u3001\u30c7\u30a8\u30d3\u30b4\u00ae\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u7720\u6c17\u306e\u5f37\u3055\u306e\u6bd4\u8f03\u3088\u308a\u3001\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae25mg\u306850mg\u3067\u306f\u7fcc\u65e5\u306e\u7720\u3055\u306b\u5927\u304d\u306a\u5dee\u306f\u306a\u304f\u3001\u7fcc\u65e5\u306e\u7720\u6c17\u306e\u983b\u5ea6\u306f\u6700\u3082\u5c11\u306a\u3044\u7d50\u679c\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6b21\u306b\u3001\u30c7\u30a8\u30d3\u30b4\u00ae5mg\u3068\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae15mg\u306820mg\u304c\u3001\u540c\u7b49\u306e\u7720\u6c17\u306e\u983b\u5ea6\u3092\u6709\u3057\u3001\u30c7\u30a8\u30d3\u30b4\u00ae10mg\u304c\u6700\u3082\u7720\u6c17\u304c\u5f37\u3044\u983b\u5ea6\u3067\u767a\u751f\u3057\u3001\u7fcc\u65e5\u306e\u6301\u3061\u8d8a\u3057\u52b9\u679c\u304c\u6b8b\u5b58\u3059\u308b\u306e\u304b\u306a\u3068\u3044\u3046\u5370\u8c61\u3092\u6301\u3061\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u4e2d\u3067\u306f\u6301\u3061\u3053\u3057\u4f5c\u7528\uff08\u7720\u6c17\uff09\u304c\u6700\u3082\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae\u3082\u3084\u306f\u308a\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u3066\u306f\u7720\u6c17\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7720\u6c17\u306f \u30c7\u30a8\u30d3\u30b4\u00ae10mg \uff1e \u30c7\u30a8\u30d3\u30b4\u00ae5mg \u2252 \u30d9\u30eb\u30bd\u30e0\u30e9\u00ae20mg\/15mg \uff1e \u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae50mg \u2252 25mg \uff1e \u30d7\u30e9\u30bb\u30dc\uff08\u507d\u85ac\uff09\u3068\u3044\u3063\u305f\u611f\u3058\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"339\" src=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/06\/image-11-800x339.png\" alt=\"\" class=\"wp-image-1240\" srcset=\"https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/06\/image-11-800x339.png 800w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/06\/image-11-400x169.png 400w, https:\/\/ito-pain.com\/blog\/wp-content\/uploads\/2026\/06\/image-11.png 850w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u88dc\u8db3\uff1a\u672c\u6587\u3067\u306f\u6709\u610f\u5dee\u306e\u3042\u3063\u305f\u3001\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae25mg\u3001\u30c7\u30a8\u30d3\u30b4\u00ae10mg\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae15mg\u306820mg\u304c\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u7720\u6c17\u304c\u5f37\u304b\u3063\u305f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u85ac\u7406\u4f5c\u7528\u7684\u306b\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae25mg\u306e\u65b9\u304c50mg\u3088\u308a\u7720\u6c17\u304c\u5f37\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u304a\u304b\u3057\u306a\u8a71\u3067\u3059\u3002\u6709\u610f\u5dee\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306b\u5de6\u53f3\u3055\u308c\u307e\u3059\u306e\u3067\u3001\u8ad6\u6587\u306e\u89e3\u91c8\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u304c\u3001\u3042\u3048\u3066\u7121\u8996\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e3\uff09J Psychiatr Res. 2020 Sep:128:68-74. doi: 10.1016\/j.jpsychires.2020.05.025. Epub 2020 May 28. Lemborexant vs suvorexant for insomnia: A systematic review and network meta-analysis Taro Kishi, Ikuo Nomura, Yuki Matsuda, Kenji Sakuma, Makoto Okuya, Toshikazu Ikuta, Nakao Iwata<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30c7\u30a8\u30d3\u30b4\u00ae\u3068\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u89e3\u6790\u306e\u7d50\u679c\u3001\u30c7\u30a8\u30d3\u30b4\u00ae10mg\u306f\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae15mg\/20mg\u3088\u308a\u7fcc\u65e5\u306e\u7720\u6c17\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e4\uff09Sleep Med. 2021 Apr:80:333-342. doi: 10.1016\/j.sleep.2021.01.048. Epub 2021 Feb 1. Long-term effectiveness and safety of lemborexant in adults with insomnia disorder: results from a phase 3 randomized clinical trial. Jane Yardley , Mikko K\u20ac , Yuichi Inoue , Kate Pinner, Carlos Perdomo ,Kohei Ishikawa , Gleb Filippov , Naoki Kubota , Margaret Moline<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6295\u85ac\u7fcc\u65e5\u306e\u7720\u6c17\u306b\u3064\u3044\u3066\u3001\u30c7\u30a8\u30d3\u30b4\u00ae10mg\u306713.1%\u3001\u30c7\u30a8\u30d3\u30b4\u00ae5mg\u30678.6%\u3001\u30d7\u30e9\u30bb\u30dc\u30671.6%\u3067\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e5\uff09Lancet Neurol. 2014 May;13(5):461-71. doi: 10.1016\/S1474-4422(14)70053-5. Epub 2014 Mar 27. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial David Michelson, Ellen Snyder, Erin Paradis, Mary Chengan-Liu, Duane B Snavely, Jill Hutzelmann, James K Walsh, Andrew D Krystal, Ruth M Benca, Martin Cohn, Christopher Lines, Thomas Roth, W Joseph Herring<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6295\u85ac\u7fcc\u65e5\u306e\u7720\u6c17\u306b\u3064\u3044\u3066\u3001\u7720\u6c17\u306e\uff05\u306f\u3001\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\uff0965\u6b73\u672a\u6e80\u306b40mg\u306765\u6b73\u4ee5\u4e0a\u306b30mg\u5185\u670d\uff08\u65e5\u672c\u3067\u8a8d\u3081\u3089\u308c\u305f\u901a\u5e38\u306e2\u500d\u306e\u91cf\u3092\u6295\u4e0e\uff09\u306713.2%\u3001\u30d7\u30e9\u30bb\u30dc\u30672.7%\u3067\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e5\u20101\uff09Biol Psychiatry. 2016 Jan 15;79(2):136-48. doi: 10.1016\/j.biopsych.2014.10.003. Epub 2014 Oct 23. Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials W Joseph Herring, Kathryn M Connor, Neely Ivgy-May, Ellen Snyder, Ken Liu, Duane B Snavely, Andrew D Krystal, James K Walsh, Ruth M Benca, Russell Rosenberg, R Bart Sangal, Kerry Budd, Jill Hutzelmann, Heather Leibensperger, Samar Froman, Christopher Lines, Thomas Roth, David Michelson<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6295\u85ac\u7fcc\u65e5\u306e\u7720\u6c17\u306b\u3064\u3044\u3066\u3001\u7720\u6c17\u306e\uff05\u306f\u30012\u56de\u306e\u8a66\u9a13\u3067\u305d\u308c\u305e\u308c\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7d50\u679c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u56de\u76ee\uff1a\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\uff0930\/40mg\uff1a10.7\uff05\u300115\/20mg\uff1a5.1\uff05\u3001\u30d7\u30e9\u30bb\u30dc\uff1a3.4%<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u56de\u76ee\uff1a\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\uff0930\/40mg\uff1a10.3\uff05\u300115\/20mg\uff1a8.4\uff05\u3001\u30d7\u30e9\u30bb\u30dc\uff1a3.1%<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e3\uff09\u3001\uff08\u6587\u732e4\uff09\u3068\uff08\u6587\u732e5\uff0c5\uff0d1\uff09\u306e\u7d50\u679c\u304b\u3089\u3001\u30c7\u30a8\u30d3\u30b4\u00ae10mg\u304c\u3001\u7fcc\u65e5\u306e\u6301\u3061\u8d8a\u3057\u4f5c\u7528\u304c\u5f37\u304f\u3001\u30c7\u30a8\u30d3\u30b4\u00ae5mg\u3068\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae15\/20mg\u304c\u3001\u540c\u7b49\u306e\u5f37\u3055\u3067\u306f\u306a\u3044\u304b\u3068\u63a8\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e6\uff09Sleep Med. 2024 Oct:122:27-34. doi: 10.1016\/j.sleep.2024.07.037. Epub 2024 Aug 2. Daridorexant in Japanese patients with insomnia disorder: A phase 3, randomized, double-blind, placebo-controlled study Naohisa Uchimura, Mitsutaka Taniguchi, Yu Ariyoshi, Yasunori Oka, Osamu Togo, Makoto Uchiyama<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6295\u85ac\u5f8c\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u7fcc\u65e5\u306e\u7720\u6c17\u3067\u3001\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae50mg\u30676.8%\u300125mg\u30673.7%\u3001\u30d7\u30e9\u30bb\u30dc\u30671.8%\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7720\u6c17\u306e\u7a0b\u5ea6\u306f\u8efd\u5ea6\u3067\u6cbb\u7642\u4e2d\u6b62\u5f8c\u306e\u53cd\u8df3\u3084\u96e2\u8131\u75c7\u72b6\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e7\uff09Sleep. 2026 Mar 11;49(3):zsaf291. doi: 10.1093\/sleep\/zsaf291. Efficacy and safety of vornorexant in Japanese patients with insomnia: a randomized, placebo-controlled phase 3 pivotal study Makoto Uchiyama, Daiji Kambe, Sayaka Hasegawa, Yumiko Imadera, Hironori Yamasaki, Naohisa Uchimura<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u7720\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6295\u85ac\u5f8c\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u7fcc\u65e5\u306e\u7720\u6c17\u3067\u3001\u30dc\u30eb\u30ba\u30a3\u00ae10mg\u30673.6%\u30015mg\u30673.1%\u3001\u30d7\u30e9\u30bb\u30dc\u30671.5%\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7720\u6c17\u306e\u7a0b\u5ea6\u306f\u8efd\u5ea6\u3067\u6cbb\u7642\u4e2d\u6b62\u5f8c\u306e\u53cd\u8df3\u3084\u96e2\u8131\u75c7\u72b6\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u732e6\uff09\u3068\uff08\u6587\u732e7\uff09\u306e\u7570\u306a\u308b\u6587\u732e\u3067\u3001\u7720\u6c17\u306e\u6570\u5b57\u3060\u3051\u3067\u6bd4\u8f03\u3059\u308b\u306e\u306f\u6b63\u78ba\u3067\u306f\u306a\u3044\u3067\u3059\u304c\u3001\u540c\u69d8\u306e\u7814\u7a76\u304c\u5b9f\u65bd\u3055\u308c\u305f\u7d50\u679c\u3092\u8a3a\u308b\u3068\u30dc\u30eb\u30ba\u30a3\u00ae5mg\u3067\u7720\u6c17\u306e\u6b8b\u5b58\u306f\u5c11\u306a\u304f\u3001\u30dc\u30eb\u30ba\u30a3\u00ae10mg\u3068\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u00ae25mg\u306f\u3001\u540c\u69d8\u306e\u7fcc\u65e5\u306e\u7720\u6c17\u306e\u6b8b\u5b58\u7a0b\u5ea6\u3067\u3042\u308b\u3068\u63a8\u5bdf\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u3068\u3081<\/p>\n\n\n\n<p 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